FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082573375> ?p ?o ?g. }

• W3082573375 endingPage "682" @default.
• W3082573375 startingPage "673" @default.
• W3082573375 abstract "<h3>Background</h3> Gastroesophageal reflux disease is a common comorbidity in idiopathic pulmonary fibrosis (IPF) and may contribute to its progression. Anti-acid therapy, such as proton pump inhibitors (PPIs), has been considered as a potential treatment option for IPF. The evidence for this treatment comes from several observational studies affected by time-related bias. <h3>Research Question</h3> Is use of PPIs in patients with IPF associated with a reduction in all-cause mortality, respiratory-related mortality, and respiratory-related hospitalization? <h3>Study Design and Methods</h3> We used the UK Clinical Practice Research Datalink to identify a cohort of patients diagnosed with IPF between 2003 and 2016. The prevalent new-user cohort design was used to match patients initiating PPIs with non-users using time-conditional propensity scores, with follow-up until death or end of observation. Cox models were used to estimate hazard ratios (HR) and 95% CIs of death and of a respiratory-related hospitalization, correcting for informative censoring by inverse probability weighting. <h3>Results</h3> There were 1,852 PPI users who were matched to 1,852 non-users identified among the cohort of patients with IPF, with a median survival of 2.8 years (mortality rate, 26.7 per 100 per year). The HR of all-cause mortality with PPI use was 1.07 (95% CI, 0.94-1.22), relative to non-use. For respiratory-related mortality, the HR was 1.10 (95% CI, 0.94-1.28) and 1.00 (95% CI, 0.86-1.16) for respiratory-related hospitalizations. <h3>Interpretation</h3> PPI use was not associated with lower mortality or hospitalization incidence in this large study conducted among patients with IPF within a real-world setting of clinical practice and designed to avoid the time-related biases affecting previous studies. PPIs may not be as beneficial in treating IPF as suggested by some studies and conditionally recommended in treatment guidelines." @default.
• W3082573375 created "2020-09-08" @default.
• W3082573375 creator A5007497866 @default.
• W3082573375 creator A5008217187 @default.
• W3082573375 creator A5046114587 @default.
• W3082573375 creator A5078877643 @default.
• W3082573375 date "2021-02-01" @default.
• W3082573375 modified "2023-09-24" @default.
• W3082573375 title "Effectiveness of Proton Pump Inhibitors in Idiopathic Pulmonary Fibrosis" @default.
• W3082573375 cites W1578396116 @default.
• W3082573375 cites W1841486778 @default.
• W3082573375 cites W1938547050 @default.
• W3082573375 cites W1963628844 @default.
• W3082573375 cites W2058234974 @default.
• W3082573375 cites W2071066672 @default.
• W3082573375 cites W2072880303 @default.
• W3082573375 cites W2105592956 @default.
• W3082573375 cites W2110054573 @default.
• W3082573375 cites W2111714917 @default.
• W3082573375 cites W2117488044 @default.
• W3082573375 cites W2119852447 @default.
• W3082573375 cites W2123700925 @default.
• W3082573375 cites W2129246173 @default.
• W3082573375 cites W2129514617 @default.
• W3082573375 cites W2134215992 @default.
• W3082573375 cites W2138871107 @default.
• W3082573375 cites W2163589808 @default.
• W3082573375 cites W2164595809 @default.
• W3082573375 cites W2167383172 @default.
• W3082573375 cites W2168666423 @default.
• W3082573375 cites W2310853658 @default.
• W3082573375 cites W2314545164 @default.
• W3082573375 cites W2328539250 @default.
• W3082573375 cites W2335121178 @default.
• W3082573375 cites W2519686100 @default.
• W3082573375 cites W2607145250 @default.
• W3082573375 cites W2626588662 @default.
• W3082573375 cites W2676312350 @default.
• W3082573375 cites W2797176335 @default.
• W3082573375 cites W2802073505 @default.
• W3082573375 cites W2903294287 @default.
• W3082573375 cites W2947958698 @default.
• W3082573375 doi "https://doi.org/10.1016/j.chest.2020.08.2080" @default.
• W3082573375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32882251" @default.
• W3082573375 hasPublicationYear "2021" @default.
• W3082573375 type Work @default.
• W3082573375 sameAs 3082573375 @default.
• W3082573375 citedByCount "27" @default.
• W3082573375 countsByYear W30825733752020 @default.
• W3082573375 countsByYear W30825733752021 @default.
• W3082573375 countsByYear W30825733752022 @default.
• W3082573375 countsByYear W30825733752023 @default.
• W3082573375 crossrefType "journal-article" @default.
• W3082573375 hasAuthorship W3082573375A5007497866 @default.
• W3082573375 hasAuthorship W3082573375A5008217187 @default.
• W3082573375 hasAuthorship W3082573375A5046114587 @default.
• W3082573375 hasAuthorship W3082573375A5078877643 @default.
• W3082573375 hasConcept C126322002 @default.
• W3082573375 hasConcept C177713679 @default.
• W3082573375 hasConcept C201903717 @default.
• W3082573375 hasConcept C207103383 @default.
• W3082573375 hasConcept C2777714996 @default.
• W3082573375 hasConcept C2778341716 @default.
• W3082573375 hasConcept C2779159551 @default.
• W3082573375 hasConcept C44249647 @default.
• W3082573375 hasConcept C50382708 @default.
• W3082573375 hasConcept C71924100 @default.
• W3082573375 hasConcept C72563966 @default.
• W3082573375 hasConceptScore W3082573375C126322002 @default.
• W3082573375 hasConceptScore W3082573375C177713679 @default.
• W3082573375 hasConceptScore W3082573375C201903717 @default.
• W3082573375 hasConceptScore W3082573375C207103383 @default.
• W3082573375 hasConceptScore W3082573375C2777714996 @default.
• W3082573375 hasConceptScore W3082573375C2778341716 @default.
• W3082573375 hasConceptScore W3082573375C2779159551 @default.
• W3082573375 hasConceptScore W3082573375C44249647 @default.
• W3082573375 hasConceptScore W3082573375C50382708 @default.
• W3082573375 hasConceptScore W3082573375C71924100 @default.
• W3082573375 hasConceptScore W3082573375C72563966 @default.
• W3082573375 hasFunder F4320320995 @default.
• W3082573375 hasFunder F4320334506 @default.
• W3082573375 hasIssue "2" @default.
• W3082573375 hasLocation W30825733751 @default.
• W3082573375 hasOpenAccess W3082573375 @default.
• W3082573375 hasPrimaryLocation W30825733751 @default.
• W3082573375 hasRelatedWork W2079315839 @default.
• W3082573375 hasRelatedWork W2158701418 @default.
• W3082573375 hasRelatedWork W2173667362 @default.
• W3082573375 hasRelatedWork W2469876530 @default.
• W3082573375 hasRelatedWork W2521415133 @default.
• W3082573375 hasRelatedWork W2528919078 @default.
• W3082573375 hasRelatedWork W2572837865 @default.
• W3082573375 hasRelatedWork W2970151791 @default.
• W3082573375 hasRelatedWork W3110151069 @default.
• W3082573375 hasRelatedWork W4229452352 @default.
• W3082573375 hasVolume "159" @default.
• W3082573375 isParatext "false" @default.
• W3082573375 isRetracted "false" @default.

• next