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• W3082574905 endingPage "4369" @default.
• W3082574905 startingPage "4357" @default.
• W3082574905 abstract "Respiratory muscle function declines with ageing, contributing to breathing complications in the elderly. Here we report greater in vitro respiratory muscle contractile function in old mice receiving supplemental NaNO3 for 14 days compared with age-matched controls. Myofibrillar protein phosphorylation, which enhances contractile function, did not change in our study - a finding inconsistent with the hypothesis that this post-translational modification is a mechanism for dietary nitrate to improve muscle contractile function. Nitrate supplementation did not change the abundance of calcium-handling proteins in the diaphragm of old mice, in contrast with findings from the limb muscles of young mice in previous studies. Our findings suggest that nitrate supplementation enhances myofibrillar protein function without affecting the phosphorylation status of key myofibrillar proteins.Inspiratory muscle (diaphragm) function declines with age, contributing to ventilatory dysfunction, impaired airway clearance, and overall decreased quality of life. Diaphragm isotonic and isometric contractile properties are reduced with ageing, including maximal specific force, shortening velocity and peak power. Contractile properties of limb muscle in both humans and rodents can be improved by dietary nitrate supplementation, but effects on the diaphragm and mechanisms behind these improvements remain poorly understood. One potential explanation underlying the nitrate effects on contractile properties is increased phosphorylation of myofibrillar proteins, a downstream outcome of nitrate reduction to nitrite and nitric oxide. We hypothesized that dietary nitrate supplementation would improve diaphragm contractile properties in aged mice. To test our hypothesis, we measured the diaphragm function of old (24 months) mice allocated to 1 mm NaNO3 in drinking water for 14 days (n = 8) or untreated water (n = 6). The maximal rate of isometric force development (∼30%) and peak power (40%) increased with nitrate supplementation (P < 0.05). There were no differences in the phosphorylation status of key myofibrillar proteins and abundance of Ca2+-release proteins in nitrate vs. control animals. In general, our study demonstrates improved diaphragm contractile function with dietary nitrate supplementation and supports the use of this strategy to improve inspiratory function in ageing populations. Additionally, our findings suggest that dietary nitrate improves diaphragm contractile properties independent of changes in abundance of Ca2+-release proteins or phosphorylation of myofibrillar proteins." @default.
• W3082574905 created "2020-09-08" @default.
• W3082574905 creator A5009978280 @default.
• W3082574905 creator A5031705013 @default.
• W3082574905 creator A5040411148 @default.
• W3082574905 creator A5061599852 @default.
• W3082574905 date "2020-08-16" @default.
• W3082574905 modified "2023-09-26" @default.
• W3082574905 title "Dietary nitrate supplementation increases diaphragm peak power in old mice" @default.
• W3082574905 cites W1511302815 @default.
• W3082574905 cites W1799879229 @default.
• W3082574905 cites W1814823830 @default.
• W3082574905 cites W1864152572 @default.
• W3082574905 cites W1947110607 @default.
• W3082574905 cites W1957992664 @default.
• W3082574905 cites W1963479847 @default.
• W3082574905 cites W1964167542 @default.
• W3082574905 cites W1973081399 @default.
• W3082574905 cites W1977376628 @default.
• W3082574905 cites W1977740428 @default.
• W3082574905 cites W1979118907 @default.
• W3082574905 cites W1979528947 @default.
• W3082574905 cites W1985227130 @default.
• W3082574905 cites W1987621820 @default.
• W3082574905 cites W1996229856 @default.
• W3082574905 cites W2001861314 @default.
• W3082574905 cites W2002479494 @default.
• W3082574905 cites W2002832586 @default.
• W3082574905 cites W2004098052 @default.
• W3082574905 cites W2004691285 @default.
• W3082574905 cites W2005411902 @default.
• W3082574905 cites W2007405130 @default.
• W3082574905 cites W2010469212 @default.
• W3082574905 cites W2011462144 @default.
• W3082574905 cites W2012588962 @default.
• W3082574905 cites W2013419112 @default.
• W3082574905 cites W2019483572 @default.
• W3082574905 cites W2022265373 @default.
• W3082574905 cites W2031758290 @default.
• W3082574905 cites W2035991920 @default.
• W3082574905 cites W2050373197 @default.
• W3082574905 cites W2052001360 @default.
• W3082574905 cites W2052610268 @default.
• W3082574905 cites W2059364425 @default.
• W3082574905 cites W2061200435 @default.
• W3082574905 cites W2070250903 @default.
• W3082574905 cites W2071052238 @default.
• W3082574905 cites W2071356846 @default.
• W3082574905 cites W2072870520 @default.
• W3082574905 cites W2078833625 @default.
• W3082574905 cites W2080782826 @default.
• W3082574905 cites W2082067048 @default.
• W3082574905 cites W2086061329 @default.
• W3082574905 cites W2092094211 @default.
• W3082574905 cites W2096708090 @default.
• W3082574905 cites W2105370141 @default.
• W3082574905 cites W2108959889 @default.
• W3082574905 cites W2113568840 @default.
• W3082574905 cites W2114325309 @default.
• W3082574905 cites W2117642435 @default.
• W3082574905 cites W2120006556 @default.
• W3082574905 cites W2123471113 @default.
• W3082574905 cites W2125963663 @default.
• W3082574905 cites W2130516476 @default.
• W3082574905 cites W2135388064 @default.
• W3082574905 cites W2136280068 @default.
• W3082574905 cites W2145437687 @default.
• W3082574905 cites W2148356899 @default.
• W3082574905 cites W2161257635 @default.
• W3082574905 cites W2161911960 @default.
• W3082574905 cites W2169949242 @default.
• W3082574905 cites W2182589089 @default.
• W3082574905 cites W2227174102 @default.
• W3082574905 cites W2264085384 @default.
• W3082574905 cites W2283061987 @default.
• W3082574905 cites W2300305376 @default.
• W3082574905 cites W2308650844 @default.
• W3082574905 cites W2310241065 @default.
• W3082574905 cites W2333957551 @default.
• W3082574905 cites W2532544513 @default.
• W3082574905 cites W2545283997 @default.
• W3082574905 cites W2558209383 @default.
• W3082574905 cites W2588984839 @default.
• W3082574905 cites W2614394717 @default.
• W3082574905 cites W2732090350 @default.
• W3082574905 cites W2777785648 @default.
• W3082574905 cites W2778249544 @default.
• W3082574905 cites W2790692940 @default.
• W3082574905 cites W2794369712 @default.
• W3082574905 cites W2799471742 @default.
• W3082574905 cites W2883886248 @default.
• W3082574905 cites W2902453870 @default.
• W3082574905 cites W2904211817 @default.
• W3082574905 cites W2916838662 @default.
• W3082574905 cites W2924950986 @default.
• W3082574905 cites W2948444586 @default.
• W3082574905 cites W2956052777 @default.
• W3082574905 cites W2963687295 @default.

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