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- W3082600324 abstract "With the development in DNA self-assembly technology, DNA origami nanostructures have been widely applied in biomedical research. Solid-state nanopores represent an emerging single-molecule sensing platform for studying nanostructures with arbitrary dimensions and physical characteristics, including DNA origami. Here, we employed relatively narrow silicon nitride nanopores to detect the deformation and translocation of DNA origami nanoplates with dimensions of approximately 60 × 54 nm. We performed translocation experiments using three nanopore diameters that are all smaller than the plat dimensions. Analysis of current blockade signals and the representative events reveals three types of translocation orientations for the nanoplates. Furthermore, by studying the electrical signal characteristics (current change and dwell time) for the different diameter pores, we obtained information about the translocation behaviors for the DNA nanoplates through different constrictions. Our investigation provides an approach to analyze the deformation and translocation of DNA origami structures." @default.
- W3082600324 created "2020-09-08" @default.
- W3082600324 creator A5004255982 @default.
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- W3082600324 date "2020-09-02" @default.
- W3082600324 modified "2023-10-16" @default.
- W3082600324 title "Deformation-Mediated Translocation of DNA Origami Nanoplates through a Narrow Solid-State Nanopore" @default.
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- W3082600324 doi "https://doi.org/10.1021/acs.analchem.0c02396" @default.
- W3082600324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32872775" @default.
- W3082600324 hasPublicationYear "2020" @default.
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