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• W3082651279 abstract "In the present work, novel 5‐((1‐benzyl‐1,2,3‐triazol‐4‐yl)methoxybenzylidene)‐2‐(arylamino)thiazol‐4‐one thiazolone incorporated triazole derivatives have been designed as tyrosinase inhibitors. The compounds were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives was evaluated. In the search for establishing a click copper‐catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air‐stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well‐organized copper iodide supported on the functionalized Fe 3 O 4 @SiO 2 core‐shell (CuI/Fe 3 O 4 @SiO 2 (TMS‐EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT‐IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET analysis. The excellent catalytic performance in ethanol with high surface area (351.7 m 2 g −1 ) and short reaction time for diverse functional groups (120–200 min), no use of toxic solvents, reusability of the catalyst, and using eco‐friendly conditions are the advantageous of this work. Moreover,the nanocatalyst can be used at least five times without any significant decrease in the yield of the reaction. The thiazolidine‐triazole derivatives 9a , 9c , 9e , and 9 g showed promising tyrosinase inhibitory activity with IC 50 values in the range of 5.90–9.81 μM. The compounds were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC 50 = 18.36 μM)." @default.
• W3082651279 created "2020-09-08" @default.
• W3082651279 creator A5002148006 @default.
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• W3082651279 date "2020-08-27" @default.
• W3082651279 modified "2023-10-14" @default.
• W3082651279 title "Synthesis of Novel Triazole Incorporated Thiazolone Motifs Having Promising Antityrosinase Activity through Green Nanocatalyst CuI‐Fe₃O₄@SiO₂ (TMS‐EDTA)" @default.
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• W3082651279 doi "https://doi.org/10.1002/aoc.5962" @default.
• W3082651279 hasPublicationYear "2020" @default.
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