FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082658738> ?p ?o ?g. }

• W3082658738 endingPage "808" @default.
• W3082658738 startingPage "808" @default.
• W3082658738 abstract "Despite the lack of effective pharmacotherapy against nonalcoholic steatohepatitis (NASH) and liver fibrosis, vitamin E (vitE) supplementation and lifestyle modifications are recommended for the management of NASH due to promising clinical results. We recently reported a positive effect of supplementation with 800 IU vitE and atorvastatin on NASH resolution in guinea pigs. In the present study, we investigated the effect of high-dose vitE therapy combined with dietary intervention against progressive NASH and advanced fibrosis in the guinea pig model. Sixty-six guinea pigs received either high-fat (HF) or standard guinea pig chow diet (Control) for 25 weeks. Prior to eight weeks of intervention, HF animals were allocated into groups; dietary intervention (Chow) or dietary intervention with 2000 IU/d vitE supplementation (CvitE). Both Chow and CvitE reduced dyslipidemia, hepatic lipid accumulation and liver weight (p < 0.05), while CvitE further decreased hepatocellular ballooning (p < 0.05). Subanalyses of individual responses within intervention groups showed significant correlation between the hepatic hallmarks of NASH and lipid accumulation vs. inflammatory state (p < 0.05). Collectively, our results indicate that individual differences in sensitivity towards intervention and inflammatory status determine the potential beneficial effect of dietary intervention and high-dose vitE supplementation. Moreover, the study suggests that inflammation is a primary target in NASH treatment." @default.
• W3082658738 created "2020-09-08" @default.
• W3082658738 creator A5011704916 @default.
• W3082658738 creator A5021545994 @default.
• W3082658738 creator A5032419808 @default.
• W3082658738 creator A5035893451 @default.
• W3082658738 creator A5088177635 @default.
• W3082658738 date "2020-09-01" @default.
• W3082658738 modified "2023-09-25" @default.
• W3082658738 title "Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation" @default.
• W3082658738 cites W1272233855 @default.
• W3082658738 cites W1832321686 @default.
• W3082658738 cites W1915485606 @default.
• W3082658738 cites W1922087192 @default.
• W3082658738 cites W1989535259 @default.
• W3082658738 cites W1995000970 @default.
• W3082658738 cites W1998383277 @default.
• W3082658738 cites W2010987575 @default.
• W3082658738 cites W2023195072 @default.
• W3082658738 cites W2034467957 @default.
• W3082658738 cites W2034520749 @default.
• W3082658738 cites W2035877503 @default.
• W3082658738 cites W2038681065 @default.
• W3082658738 cites W2042981158 @default.
• W3082658738 cites W2052701666 @default.
• W3082658738 cites W2060809684 @default.
• W3082658738 cites W2062812115 @default.
• W3082658738 cites W2067740038 @default.
• W3082658738 cites W2073874316 @default.
• W3082658738 cites W2074503081 @default.
• W3082658738 cites W2075668708 @default.
• W3082658738 cites W2091106363 @default.
• W3082658738 cites W2093182588 @default.
• W3082658738 cites W2097034899 @default.
• W3082658738 cites W2105405430 @default.
• W3082658738 cites W2111951337 @default.
• W3082658738 cites W2125553677 @default.
• W3082658738 cites W2129275826 @default.
• W3082658738 cites W2136612314 @default.
• W3082658738 cites W2157338541 @default.
• W3082658738 cites W2157671355 @default.
• W3082658738 cites W2171753559 @default.
• W3082658738 cites W2256028451 @default.
• W3082658738 cites W2277891177 @default.
• W3082658738 cites W2294346279 @default.
• W3082658738 cites W2295135624 @default.
• W3082658738 cites W2323606868 @default.
• W3082658738 cites W2410429105 @default.
• W3082658738 cites W2479279117 @default.
• W3082658738 cites W2509045298 @default.
• W3082658738 cites W2511630563 @default.
• W3082658738 cites W2527269009 @default.
• W3082658738 cites W2550736376 @default.
• W3082658738 cites W2622768563 @default.
• W3082658738 cites W2734724639 @default.
• W3082658738 cites W2744982526 @default.
• W3082658738 cites W2755181058 @default.
• W3082658738 cites W2759997926 @default.
• W3082658738 cites W2773466959 @default.
• W3082658738 cites W2773827782 @default.
• W3082658738 cites W2787406891 @default.
• W3082658738 cites W2800368679 @default.
• W3082658738 cites W2801929531 @default.
• W3082658738 cites W2807079449 @default.
• W3082658738 cites W2810629608 @default.
• W3082658738 cites W2889932786 @default.
• W3082658738 cites W2890780033 @default.
• W3082658738 cites W2907399017 @default.
• W3082658738 cites W2911738536 @default.
• W3082658738 cites W2921545853 @default.
• W3082658738 cites W2965516669 @default.
• W3082658738 cites W2969484887 @default.
• W3082658738 cites W2982480446 @default.
• W3082658738 cites W2990008267 @default.
• W3082658738 cites W3143409077 @default.
• W3082658738 cites W4241721607 @default.
• W3082658738 doi "https://doi.org/10.3390/antiox9090808" @default.
• W3082658738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7555643" @default.
• W3082658738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32882802" @default.
• W3082658738 hasPublicationYear "2020" @default.
• W3082658738 type Work @default.
• W3082658738 sameAs 3082658738 @default.
• W3082658738 citedByCount "6" @default.
• W3082658738 countsByYear W30826587382021 @default.
• W3082658738 countsByYear W30826587382022 @default.
• W3082658738 crossrefType "journal-article" @default.
• W3082658738 hasAuthorship W3082658738A5011704916 @default.
• W3082658738 hasAuthorship W3082658738A5021545994 @default.
• W3082658738 hasAuthorship W3082658738A5032419808 @default.
• W3082658738 hasAuthorship W3082658738A5035893451 @default.
• W3082658738 hasAuthorship W3082658738A5088177635 @default.
• W3082658738 hasBestOaLocation W30826587381 @default.
• W3082658738 hasConcept C126322002 @default.
• W3082658738 hasConcept C134018914 @default.
• W3082658738 hasConcept C2776914184 @default.
• W3082658738 hasConcept C2777551382 @default.
• W3082658738 hasConcept C2778004101 @default.
• W3082658738 hasConcept C2778096610 @default.

• next