FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082700051> ?p ?o ?g. }

• W3082700051 endingPage "113301" @default.
• W3082700051 startingPage "113301" @default.
• W3082700051 abstract "Xuebijing (XBJ) injection is a Chinese medicine containing extracts from Carthamus tinctorius L. (Carthami Flos, hong hua, Asteraceae), Paeonia lactiflora Pall. (Paeoniae radix rubra, chi shao, Ranunculaceae), Ligusticum chuanxiong Hort. (Chuanxiong Rhizoma, chuan xiong, Umbelliferae), Salvia miltiorrhiza Bge. (Salviae miltiorrhizae Radix Et Rhizoma, dan shen, Labiatae) and Angelica sinensis (Oliv.) Diels (Angelicae sinensis Radix, dang gui, Umbelliferae). It has been approved for the treatment of sepsis in China since 2004 and has been widely used as an add-on treatment for sepsis or septic shock with few side effects. The aim of the present review was to analyse up-to-date information related to the treatment of sepsis with XBJ, including the bioactive constituents, clinical studies and potential mechanisms, and to discuss possible scientific gaps, to provide a reliable reference for future studies. Scientific resources concentrating on treating sepsis with XBJ were searched through PubMed, the Chinese National Knowledge Infrastructure (CNKI) and WanFang databases from inception to November 2018. Dissertations were also searched, and eligible dissertations were selected. Studies related to the identification of constituents, bioactive components and their targets of action or pathways, clinical trials, and animal or cellular experiments that explored pharmacological mechanisms were manually selected. The quality of reporting and methodology of the included pharmacological experiments were assessed using the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE)'s risk of bias tool. A total of 108 relative studies were eventually included, containing 12 bioactivity research studies, 10 systematic reviews on clinical trials and 86 animal or cellular experiments. We noted that as identification methods progressed, further constituents could be detected in XBJ. XBJ was also found to have “multi-ingredient, multi-target and multi-pathway” effects. The systematic review revealed that XBJ could improve the 28-day mortality and other indexes, such as the APACHE II score, body temperature, and white blood cell (WBC) count, to some extent. A major organ protection effect was demonstrated in septic rats. Pharmacological investigations suggested that XBJ acts in both the early and late stages of sepsis by anti-inflammatory, anti-coagulation, immune regulation, vascular endothelial protection, anti-oxidative stress and other mechanisms. However, most of the included studies were poorly reported, and the risk of bias was unclear. With respect to the multiple therapeutic mechanisms contributing to both the early and late stages of sepsis, the multiple effective constituents detected and randomized controlled trials (RCTs) performed to prove its efficacy, XBJ is a promising therapy for the treatment of sepsis. However, although XBJ has shown some efficacy for the treatment of sepsis, there are currently some scientific gaps. More studies concerning the pharmacokinetics, interactions with antibiotics, real-world efficacy and safety, pharmacological mechanisms of the bioactive components and large-scale clinical trials should be conducted in the future." @default.
• W3082700051 created "2020-09-08" @default.
• W3082700051 creator A5007884136 @default.
• W3082700051 creator A5008232261 @default.
• W3082700051 creator A5011762184 @default.
• W3082700051 creator A5013294440 @default.
• W3082700051 creator A5013736647 @default.
• W3082700051 creator A5014829857 @default.
• W3082700051 creator A5039665300 @default.
• W3082700051 creator A5042609322 @default.
• W3082700051 creator A5080640637 @default.
• W3082700051 date "2021-01-01" @default.
• W3082700051 modified "2023-10-14" @default.
• W3082700051 title "The current evidence for the treatment of sepsis with Xuebijing injection: Bioactive constituents, findings of clinical studies and potential mechanisms" @default.
• W3082700051 cites W1578821085 @default.
• W3082700051 cites W1879207397 @default.
• W3082700051 cites W1970919362 @default.
• W3082700051 cites W1973772947 @default.
• W3082700051 cites W1985391068 @default.
• W3082700051 cites W1988769907 @default.
• W3082700051 cites W1989832114 @default.
• W3082700051 cites W1994610638 @default.
• W3082700051 cites W1995744610 @default.
• W3082700051 cites W1997800933 @default.
• W3082700051 cites W2001439220 @default.
• W3082700051 cites W2007473062 @default.
• W3082700051 cites W2009797710 @default.
• W3082700051 cites W2017929603 @default.
• W3082700051 cites W2027065937 @default.
• W3082700051 cites W2027198537 @default.
• W3082700051 cites W2031112248 @default.
• W3082700051 cites W2032251005 @default.
• W3082700051 cites W2036117709 @default.
• W3082700051 cites W2036490924 @default.
• W3082700051 cites W2044986214 @default.
• W3082700051 cites W2049069390 @default.
• W3082700051 cites W2050399575 @default.
• W3082700051 cites W2058571677 @default.
• W3082700051 cites W2071326128 @default.
• W3082700051 cites W2072339607 @default.
• W3082700051 cites W2082890018 @default.
• W3082700051 cites W2082976004 @default.
• W3082700051 cites W2086303909 @default.
• W3082700051 cites W2087203965 @default.
• W3082700051 cites W2094171424 @default.
• W3082700051 cites W2097476575 @default.
• W3082700051 cites W2098811327 @default.
• W3082700051 cites W2098865069 @default.
• W3082700051 cites W2107817160 @default.
• W3082700051 cites W2108242700 @default.
• W3082700051 cites W2110971703 @default.
• W3082700051 cites W2115633980 @default.
• W3082700051 cites W2120509389 @default.
• W3082700051 cites W2125909902 @default.
• W3082700051 cites W2135382346 @default.
• W3082700051 cites W2141862597 @default.
• W3082700051 cites W2141868068 @default.
• W3082700051 cites W2144589352 @default.
• W3082700051 cites W2148126661 @default.
• W3082700051 cites W2148744493 @default.
• W3082700051 cites W2150107812 @default.
• W3082700051 cites W2164714222 @default.
• W3082700051 cites W2280404143 @default.
• W3082700051 cites W2305941028 @default.
• W3082700051 cites W2309066444 @default.
• W3082700051 cites W2322375144 @default.
• W3082700051 cites W2326277133 @default.
• W3082700051 cites W2332438258 @default.
• W3082700051 cites W2339656438 @default.
• W3082700051 cites W2341811425 @default.
• W3082700051 cites W2474224145 @default.
• W3082700051 cites W2546685135 @default.
• W3082700051 cites W2550220408 @default.
• W3082700051 cites W2551679113 @default.
• W3082700051 cites W2568886428 @default.
• W3082700051 cites W2571641922 @default.
• W3082700051 cites W2753159650 @default.
• W3082700051 cites W2761146002 @default.
• W3082700051 cites W2768146862 @default.
• W3082700051 cites W2769276025 @default.
• W3082700051 cites W2789578191 @default.
• W3082700051 cites W2790840265 @default.
• W3082700051 cites W2794306624 @default.
• W3082700051 cites W2806098891 @default.
• W3082700051 cites W2890637229 @default.
• W3082700051 cites W2901929987 @default.
• W3082700051 cites W2904212771 @default.
• W3082700051 cites W2922369759 @default.
• W3082700051 cites W2948924403 @default.
• W3082700051 cites W3045454797 @default.
• W3082700051 cites W3140469078 @default.
• W3082700051 cites W4245492581 @default.
• W3082700051 cites W638613648 @default.
• W3082700051 cites W879479010 @default.
• W3082700051 doi "https://doi.org/10.1016/j.jep.2020.113301" @default.
• W3082700051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32860891" @default.
• W3082700051 hasPublicationYear "2021" @default.
• W3082700051 type Work @default.

• next