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• W3082806982 endingPage "140525" @default.
• W3082806982 startingPage "140525" @default.
• W3082806982 abstract "The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the phenotype of tumoral cells and have significant implications in cancer development and progression. In this study we performed an in vitro heterotypic signaling assays by evaluating the proteome diversity of human dermal fibroblasts after stimulation with the conditioned media obtained from malignant melanoma cells. In addition, we also evaluated the changes in the proteome of melanoma cells after stimulation with their own conditioned media as well as with the conditioned medium from melanoma-stimulated fibroblasts. Our results revealed a clear rearrangement in the proteome of stromal and malignant cells upon crosstalk of soluble mediators. The main proteome signature of fibroblasts stimulated with melanoma conditioned medium was related to protein synthesis, which indicates that this process might be an early response of stromal cells. In addition, the conditioned medium derived from ‘primed’ stromal cells (melanoma-stimulated fibroblasts) was more effective in altering the functional phenotype (cell migration) of malignant cells than the conditioned medium from non-stimulated fibroblasts. Collectively, self- and cross-stimulation may play a key role in shaping the tumor microenvironment and enable tumoral cells to succeed in the process of melanoma progression and metastasis. Although the proteome landscape of cells participating in such a heterotypic signaling represents a snapshot of a highly dynamic state, understanding the diversity of proteins and enriched biological pathways resulting from stimulated cell states may allow for targeting specific cell regulatory motifs involved in melanoma progression and metastasis. • Soluble mediators within the tumoral microenvironment shape cell phenotypes • Crosstalk between stromal and melanoma cells resulted in rearrangements in their proteomes • The main proteome signature of melanoma-stimulated cells was related to protein synthesis • Conditioned medium from ‘primed’ stromal cells altered cell migration of malignant cells" @default.
• W3082806982 created "2020-09-08" @default.
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• W3082806982 date "2020-12-01" @default.
• W3082806982 modified "2023-10-03" @default.
• W3082806982 title "Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells" @default.
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• W3082806982 doi "https://doi.org/10.1016/j.bbapap.2020.140525" @default.
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