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- W3082807744 endingPage "10153" @default.
- W3082807744 startingPage "10141" @default.
- W3082807744 abstract "Despite dramatic advances in drug discovery over the decades, effective therapeutic strategies for cancers treatment are still in urgent demands. PROteolysis TArgeting Chimera (PROTAC), a novel therapeutic modality, has been vigorously promoted in preclinical and clinical applications. Unlike small molecule PROTAC, peptide PROTAC (p-PROTAC) with advantages of high specificity and low toxicity, while avoiding the limitations of shallow binding pockets through large interacting surfaces, provides promising substitutions for E3 ubiquitin ligase complex-mediated ubiquitination of undruggable proteins. It is worth noting that successful applications of p-PROTAC still have some obstacles, including low stability and poor membrane permeability. Hence, we highlight that p-PROTAC combined with cell-penetrating peptides, constrained conformation technique, and targeted delivery systems could be the future efforts for potential translational research." @default.
- W3082807744 created "2020-09-08" @default.
- W3082807744 creator A5002855077 @default.
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- W3082807744 date "2020-01-01" @default.
- W3082807744 modified "2023-10-02" @default.
- W3082807744 title "The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination" @default.
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