Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082808217> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3082808217 endingPage "870" @default.
- W3082808217 startingPage "865" @default.
- W3082808217 abstract "Human epidermal growth factor receptor 2 (HER2) protein overexpression is associated with HER2 gene amplification, a critical driver oncogenetic change in gastric cancer. HER2 heterogeneity in advanced gastric cancer is associated with a poor prognosis and affects the clinical efficacy of trastuzumab. However, the mechanisms of HER2 heterogeneity are not fully understood. Here, we examined whether HER2 heterogeneous gastric cancer exhibited intratumoral genetic heterogeneity in other cancer‐related genes. Two cases of advanced gastric cancer with HER2 heterogeneity were selected, and samples of HER2‐positive and HER2‐negative areas in each case were analyzed using a cancer‐associated multiple gene panel. In both cases, TP53 mutations were observed in both HER2‐positive and HER2‐negative areas, whereas many of the potential driver and passenger mutations differed between HER2‐positive and HER2‐negative areas. Overall, our findings demonstrated that HER2 heterogeneous gastric cancer exhibited intratumoral genetic heterogeneity in other cancer‐related genes and that the molecular mechanisms could differ between HER2‐positive and ‐negative areas." @default.
- W3082808217 created "2020-09-08" @default.
- W3082808217 creator A5003350996 @default.
- W3082808217 creator A5005183405 @default.
- W3082808217 creator A5059206743 @default.
- W3082808217 creator A5069624409 @default.
- W3082808217 creator A5073366280 @default.
- W3082808217 creator A5079207845 @default.
- W3082808217 creator A5082390079 @default.
- W3082808217 date "2020-09-01" @default.
- W3082808217 modified "2023-09-26" @default.
- W3082808217 title "Cancer‐related gene mutations and intratumoral genetic heterogeneity in human epidermal growth factor receptor 2 heterogeneous gastric cancer" @default.
- W3082808217 cites W1545025751 @default.
- W3082808217 cites W1945181719 @default.
- W3082808217 cites W1987009448 @default.
- W3082808217 cites W2000213852 @default.
- W3082808217 cites W2029678186 @default.
- W3082808217 cites W2100439220 @default.
- W3082808217 cites W2289732113 @default.
- W3082808217 cites W2797845812 @default.
- W3082808217 cites W2885533673 @default.
- W3082808217 cites W2965889803 @default.
- W3082808217 doi "https://doi.org/10.1111/pin.13004" @default.
- W3082808217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32869925" @default.
- W3082808217 hasPublicationYear "2020" @default.
- W3082808217 type Work @default.
- W3082808217 sameAs 3082808217 @default.
- W3082808217 citedByCount "0" @default.
- W3082808217 crossrefType "journal-article" @default.
- W3082808217 hasAuthorship W3082808217A5003350996 @default.
- W3082808217 hasAuthorship W3082808217A5005183405 @default.
- W3082808217 hasAuthorship W3082808217A5059206743 @default.
- W3082808217 hasAuthorship W3082808217A5069624409 @default.
- W3082808217 hasAuthorship W3082808217A5073366280 @default.
- W3082808217 hasAuthorship W3082808217A5079207845 @default.
- W3082808217 hasAuthorship W3082808217A5082390079 @default.
- W3082808217 hasConcept C104317684 @default.
- W3082808217 hasConcept C121608353 @default.
- W3082808217 hasConcept C126322002 @default.
- W3082808217 hasConcept C127716648 @default.
- W3082808217 hasConcept C143998085 @default.
- W3082808217 hasConcept C2779438470 @default.
- W3082808217 hasConcept C2779786085 @default.
- W3082808217 hasConcept C501734568 @default.
- W3082808217 hasConcept C502942594 @default.
- W3082808217 hasConcept C530470458 @default.
- W3082808217 hasConcept C54355233 @default.
- W3082808217 hasConcept C64618202 @default.
- W3082808217 hasConcept C71924100 @default.
- W3082808217 hasConcept C86803240 @default.
- W3082808217 hasConceptScore W3082808217C104317684 @default.
- W3082808217 hasConceptScore W3082808217C121608353 @default.
- W3082808217 hasConceptScore W3082808217C126322002 @default.
- W3082808217 hasConceptScore W3082808217C127716648 @default.
- W3082808217 hasConceptScore W3082808217C143998085 @default.
- W3082808217 hasConceptScore W3082808217C2779438470 @default.
- W3082808217 hasConceptScore W3082808217C2779786085 @default.
- W3082808217 hasConceptScore W3082808217C501734568 @default.
- W3082808217 hasConceptScore W3082808217C502942594 @default.
- W3082808217 hasConceptScore W3082808217C530470458 @default.
- W3082808217 hasConceptScore W3082808217C54355233 @default.
- W3082808217 hasConceptScore W3082808217C64618202 @default.
- W3082808217 hasConceptScore W3082808217C71924100 @default.
- W3082808217 hasConceptScore W3082808217C86803240 @default.
- W3082808217 hasIssue "11" @default.
- W3082808217 hasLocation W30828082171 @default.
- W3082808217 hasOpenAccess W3082808217 @default.
- W3082808217 hasPrimaryLocation W30828082171 @default.
- W3082808217 hasRelatedWork W111573635 @default.
- W3082808217 hasRelatedWork W1722328147 @default.
- W3082808217 hasRelatedWork W2013223170 @default.
- W3082808217 hasRelatedWork W2066747782 @default.
- W3082808217 hasRelatedWork W2593475799 @default.
- W3082808217 hasRelatedWork W2934076975 @default.
- W3082808217 hasRelatedWork W3031780582 @default.
- W3082808217 hasRelatedWork W4322772378 @default.
- W3082808217 hasRelatedWork W812572266 @default.
- W3082808217 hasRelatedWork W2342209702 @default.
- W3082808217 hasVolume "70" @default.
- W3082808217 isParatext "false" @default.
- W3082808217 isRetracted "false" @default.
- W3082808217 magId "3082808217" @default.
- W3082808217 workType "article" @default.