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• W3082814770 abstract "Progress in the development of new therapies for cystic fibrosis (CF) has benefited from therapeutically responsive biomarkers to streamline drug development. Paradoxically, these response biomarkers have been proven to be essential even in the presence of data demonstrating a lack of correlation with clinical outcomes across individuals with CF. This finding is unsurprising, particularly in the setting of a rare disease given complex disease processes and an often-limited pool of clinically effective therapies by which to link biomarkers and clinical responsiveness. While many response biomarkers will be unable to progress from their status as markers of biological efficacy to either established correlates of clinical efficacy or surrogate endpoints, they remain critical to the overall success of therapeutic development." @default.
• W3082814770 created "2020-09-08" @default.
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• W3082814770 creator A5062599923 @default.
• W3082814770 date "2020-12-01" @default.
• W3082814770 modified "2023-10-16" @default.
• W3082814770 title "Accelerated Approval or Risk Reduction? How Response Biomarkers Advance Therapeutics through Clinical Trials in Cystic Fibrosis" @default.
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• W3082814770 doi "https://doi.org/10.1016/j.molmed.2020.08.002" @default.
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