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• W3082816887 abstract "The mouse motor cortex exhibits spontaneous activity in the form of temporal sequences of neuronal ensembles in vitro without the need of tissue stimulation. These neuronal ensembles are defined as groups of neurons with a strong correlation between its firing patterns, generating what appears to be a predetermined neural conduction mode that needs study. Each ensemble is commonly accompanied by one or more parvalbumin expressing neurons (PV+) or fast spiking interneurons. Many of these interneurons have functional connections between them, helping to form a circuit configuration similar to a small-world network. However, rich club metrics show that most connected neurons are neurons not expressing parvalbumin, mainly pyramidal neurons (PV-) suggesting feed-forward propagation through pyramidal cells. Ensembles with PV+ neurons are connected to these hubs. When ligand-gated fast GABAergic transmission is blocked, temporal sequences of ensembles collapse into a unique synchronous and recurrent ensemble, showing the need of inhibition for coding cortical spontaneous activity. This new ensemble has a duration and electrophysiological characteristics of brief recurrent interictal epileptiform discharges (IEDs) composed by the coactivity of both PV- and PV+ neurons, demonstrating that GABA transmission impedes its occurrence. Synchronous ensembles are clearly divided into two clusters one of them lasting longer and mainly composed by PV+ neurons. Because an ictal-like event was not recorded after several minutes of IEDs recording, it is inferred that an external stimulus and/or fast GABA transmission are necessary for its appearance, making this preparation ideal to study both the neuronal machinery to encode cortical spontaneous activity and its transformation into brief non-ictal epileptiform discharges." @default.
• W3082816887 created "2020-09-08" @default.
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• W3082816887 date "2020-10-01" @default.
• W3082816887 modified "2023-10-18" @default.
• W3082816887 title "Spontaneous Activity of Neuronal Ensembles in Mouse Motor Cortex: Changes after GABAergic Blockade" @default.
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• W3082816887 cites W1853425391 @default.
• W3082816887 cites W1921182138 @default.
• W3082816887 cites W1963765956 @default.
• W3082816887 cites W1968905959 @default.
• W3082816887 cites W1974803102 @default.
• W3082816887 cites W1975389666 @default.
• W3082816887 cites W1975483835 @default.
• W3082816887 cites W1977369305 @default.
• W3082816887 cites W1977906889 @default.
• W3082816887 cites W1980837328 @default.
• W3082816887 cites W1990703642 @default.
• W3082816887 cites W1994801733 @default.
• W3082816887 cites W1996874802 @default.
• W3082816887 cites W1997089134 @default.
• W3082816887 cites W1999653836 @default.
• W3082816887 cites W2001408338 @default.
• W3082816887 cites W2002216713 @default.
• W3082816887 cites W2011267914 @default.
• W3082816887 cites W2012559638 @default.
• W3082816887 cites W2025603247 @default.
• W3082816887 cites W2028756092 @default.
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• W3082816887 cites W2047378045 @default.
• W3082816887 cites W2047712100 @default.
• W3082816887 cites W2052394872 @default.
• W3082816887 cites W2054465718 @default.
• W3082816887 cites W2059370679 @default.
• W3082816887 cites W2064685631 @default.
• W3082816887 cites W2064869244 @default.
• W3082816887 cites W2067474937 @default.
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• W3082816887 cites W2077804523 @default.
• W3082816887 cites W2078794894 @default.
• W3082816887 cites W2085048370 @default.
• W3082816887 cites W2086327058 @default.
• W3082816887 cites W2089512406 @default.
• W3082816887 cites W2096131894 @default.
• W3082816887 cites W2104731571 @default.
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• W3082816887 cites W2172122397 @default.
• W3082816887 cites W2185541914 @default.
• W3082816887 cites W2283006476 @default.
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• W3082816887 doi "https://doi.org/10.1016/j.neuroscience.2020.08.025" @default.
• W3082816887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32860933" @default.
• W3082816887 hasPublicationYear "2020" @default.
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