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• W3082913879 endingPage "4005" @default.
• W3082913879 startingPage "4005" @default.
• W3082913879 abstract "Memantine (3,5-dimethyladamantan-1-amine) is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist approved for treatment of moderate-to-severe Alzheimer’s disease (AD), a neurodegenerative condition characterized by a progressive cognitive decline. Unfortunately, memantine as well as the other class of drugs licensed for AD treatment acting as acetylcholinesterase inhibitors (AChEIs), provide only symptomatic relief. Thus, the urgent need in AD drug development is for disease-modifying therapies that may require approaching targets from more than one path at once or multiple targets simultaneously. Indeed, increasing evidence suggests that the modulation of a single neurotransmitter system represents a reductive approach to face the complexity of AD. Memantine is viewed as a privileged NMDAR-directed structure, and therefore, represents the driving motif in the design of a variety of multi-target directed ligands (MTDLs). In this review, we present selected examples of small molecules recently designed as MTDLs to contrast AD, by combining in a single entity the amantadine core of memantine with the pharmacophoric features of known neuroprotectants, such as antioxidant agents, AChEIs and Aβ-aggregation inhibitors." @default.
• W3082913879 created "2020-09-08" @default.
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• W3082913879 creator A5071816363 @default.
• W3082913879 date "2020-09-02" @default.
• W3082913879 modified "2023-10-18" @default.
• W3082913879 title "Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease" @default.
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• W3082913879 doi "https://doi.org/10.3390/molecules25174005" @default.
• W3082913879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7504780" @default.
• W3082913879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32887400" @default.
• W3082913879 hasPublicationYear "2020" @default.
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