Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082926190> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3082926190 abstract "Background The VIGOUR Study was a randomised, double-blind, clinical trial assessing the GI safety of rofecoxib 50 mg. once daily (n = 4047) versus naproxen 500 mg twice daily (n = 4029) in the patients with rheumatoid arthritis. The mean age was 58 years; 80% of patients were female; 8% had a prior history of a GI ulcer or bleed; 82% reported NSAID use at baseline; 21% reported dyspepsia within 14 days prior to baseline; the treatment groups were not different in these respects. The median duration of follow-up 9.0 months, the maximum was 13 months. Objectives To compare the rates of hospitalisation and mean number of outpatient healthcare contacts associated with upper GI perforation, ulcer, or bleeding (PUB) in patients treated with rofecoxib, a highly selective COX-2 inhibitor, vs. naproxen in the VIGOUR Study. Methods The proportions of patients with hospitalizations for PUB in the two treatment groups were compared for all randomised patients. All PUBs were confirmed by an outside adjudication committee. The proportions of patients hospitalised for PUB, and the rates of PUB hospitalisation (per 100 patient-years, and based on the Kaplan-Meier method) were compared between treatment groups. Additional analyses compare proportions of PUB patients hospitalised and the mean number of outpatient contacts given a PUB event. Results The incidence of confirmed PUBs, the primary endpoint in VIGOUR, was significantly lower with rofecoxib compared to naproxen (2.1 vs 4.5% per year; p Conclusion In the VIGOUR Study, RA patients treated with the highly selective COX-2 inhibitor rofecoxib for up to 13 months had significantly fewer PUBs and required fewer hospitalizations for PUBs than patients treated with naproxen." @default.
- W3082926190 created "2020-09-08" @default.
- W3082926190 creator A5017447759 @default.
- W3082926190 creator A5022896364 @default.
- W3082926190 creator A5033084891 @default.
- W3082926190 creator A5044062020 @default.
- W3082926190 creator A5044278789 @default.
- W3082926190 creator A5051483583 @default.
- W3082926190 creator A5069410791 @default.
- W3082926190 date "2001-06-01" @default.
- W3082926190 modified "2023-09-26" @default.
- W3082926190 title "OP0137 Less healthcare resource utilisation for perforations, ulcers and bleeds with rofecoxib vs. naproxen in the vigour (vioxx gi outcomes research) study" @default.
- W3082926190 doi "https://doi.org/10.1136/annrheumdis-2001.862" @default.
- W3082926190 hasPublicationYear "2001" @default.
- W3082926190 type Work @default.
- W3082926190 sameAs 3082926190 @default.
- W3082926190 citedByCount "0" @default.
- W3082926190 crossrefType "proceedings-article" @default.
- W3082926190 hasAuthorship W3082926190A5017447759 @default.
- W3082926190 hasAuthorship W3082926190A5022896364 @default.
- W3082926190 hasAuthorship W3082926190A5033084891 @default.
- W3082926190 hasAuthorship W3082926190A5044062020 @default.
- W3082926190 hasAuthorship W3082926190A5044278789 @default.
- W3082926190 hasAuthorship W3082926190A5051483583 @default.
- W3082926190 hasAuthorship W3082926190A5069410791 @default.
- W3082926190 hasBestOaLocation W30829261901 @default.
- W3082926190 hasConcept C120665830 @default.
- W3082926190 hasConcept C121332964 @default.
- W3082926190 hasConcept C126322002 @default.
- W3082926190 hasConcept C141071460 @default.
- W3082926190 hasConcept C142724271 @default.
- W3082926190 hasConcept C181199279 @default.
- W3082926190 hasConcept C185592680 @default.
- W3082926190 hasConcept C191897082 @default.
- W3082926190 hasConcept C192562407 @default.
- W3082926190 hasConcept C203092338 @default.
- W3082926190 hasConcept C204787440 @default.
- W3082926190 hasConcept C2776259030 @default.
- W3082926190 hasConcept C2777575956 @default.
- W3082926190 hasConcept C2778115740 @default.
- W3082926190 hasConcept C2778456384 @default.
- W3082926190 hasConcept C2778527123 @default.
- W3082926190 hasConcept C2778582115 @default.
- W3082926190 hasConcept C2779689624 @default.
- W3082926190 hasConcept C535046627 @default.
- W3082926190 hasConcept C55493867 @default.
- W3082926190 hasConcept C61511704 @default.
- W3082926190 hasConcept C71924100 @default.
- W3082926190 hasConceptScore W3082926190C120665830 @default.
- W3082926190 hasConceptScore W3082926190C121332964 @default.
- W3082926190 hasConceptScore W3082926190C126322002 @default.
- W3082926190 hasConceptScore W3082926190C141071460 @default.
- W3082926190 hasConceptScore W3082926190C142724271 @default.
- W3082926190 hasConceptScore W3082926190C181199279 @default.
- W3082926190 hasConceptScore W3082926190C185592680 @default.
- W3082926190 hasConceptScore W3082926190C191897082 @default.
- W3082926190 hasConceptScore W3082926190C192562407 @default.
- W3082926190 hasConceptScore W3082926190C203092338 @default.
- W3082926190 hasConceptScore W3082926190C204787440 @default.
- W3082926190 hasConceptScore W3082926190C2776259030 @default.
- W3082926190 hasConceptScore W3082926190C2777575956 @default.
- W3082926190 hasConceptScore W3082926190C2778115740 @default.
- W3082926190 hasConceptScore W3082926190C2778456384 @default.
- W3082926190 hasConceptScore W3082926190C2778527123 @default.
- W3082926190 hasConceptScore W3082926190C2778582115 @default.
- W3082926190 hasConceptScore W3082926190C2779689624 @default.
- W3082926190 hasConceptScore W3082926190C535046627 @default.
- W3082926190 hasConceptScore W3082926190C55493867 @default.
- W3082926190 hasConceptScore W3082926190C61511704 @default.
- W3082926190 hasConceptScore W3082926190C71924100 @default.
- W3082926190 hasLocation W30829261901 @default.
- W3082926190 hasOpenAccess W3082926190 @default.
- W3082926190 hasPrimaryLocation W30829261901 @default.
- W3082926190 hasRelatedWork W1805648369 @default.
- W3082926190 hasRelatedWork W1963960033 @default.
- W3082926190 hasRelatedWork W1998885851 @default.
- W3082926190 hasRelatedWork W2011989830 @default.
- W3082926190 hasRelatedWork W2016503139 @default.
- W3082926190 hasRelatedWork W2022630327 @default.
- W3082926190 hasRelatedWork W2060835590 @default.
- W3082926190 hasRelatedWork W2073636239 @default.
- W3082926190 hasRelatedWork W2129554354 @default.
- W3082926190 hasRelatedWork W2141706104 @default.
- W3082926190 hasRelatedWork W2328892908 @default.
- W3082926190 hasRelatedWork W2339651132 @default.
- W3082926190 hasRelatedWork W2396582809 @default.
- W3082926190 hasRelatedWork W2417277728 @default.
- W3082926190 hasRelatedWork W2519770441 @default.
- W3082926190 hasRelatedWork W2896808847 @default.
- W3082926190 hasRelatedWork W3030147279 @default.
- W3082926190 hasRelatedWork W3091680144 @default.
- W3082926190 hasRelatedWork W6314235 @default.
- W3082926190 hasRelatedWork W2181395097 @default.
- W3082926190 isParatext "false" @default.
- W3082926190 isRetracted "false" @default.
- W3082926190 magId "3082926190" @default.
- W3082926190 workType "article" @default.