FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082943067> ?p ?o ?g. }

• W3082943067 endingPage "115568" @default.
• W3082943067 startingPage "115568" @default.
• W3082943067 abstract "Previous studies have associated the risk of autism spectrum disorder (ASD) with increased exposures to metals and metalloids such as arsenic. In this study, we used an animal-to-human translational strategy to identify key molecular changes that potentially mediated the effects of arsenic exposures on ASD development. In a previously established rat model, we have induced autistic behaviors in rat pups with gestational arsenic exposures (10 and 45 μg/L As2O3 in drinking water). Neuronal apoptosis and the associated epigenetic dysregulations in frontal cortex were assayed to screen potential mediating pathways, which were subsequently validated with qPCR, western blotting, and immunohistochemistry analyses. Furthermore, the identified pathway, along with serum levels of 26 elements including arsenic, were characterized in a case-control study with 21 ASD children and 21 age-matched healthy controls. In animals, we found that arsenic exposures caused difficulties of social interaction and increased stereotypic behaviors in a dose-dependent manner, accompanied by increased neuronal apoptosis and upregulation of Hipk2-p53 pathway in the frontal cortex. In humans, we found that serum levels of Hipk2 and p53 were 24.7 (95%CI: 8.5 to 43.4) % and 23.7 (95%CI: 10.5 to 38.5) % higher in ASD children than in healthy controls. ASD children had significantly higher serum levels of 15 elements, among which arsenic, silicon, strontium, and vanadium were positively associated with both Hipk2 and p53. Results from both the rat arsenic exposure and human case-control studies suggest a likely role of Hipk2-p53 pathway in ASD development induced by exposures to environmental pollutants such as arsenic." @default.
• W3082943067 created "2020-09-08" @default.
• W3082943067 creator A5003918874 @default.
• W3082943067 creator A5008308356 @default.
• W3082943067 creator A5025172140 @default.
• W3082943067 creator A5028199089 @default.
• W3082943067 creator A5030543101 @default.
• W3082943067 creator A5048307710 @default.
• W3082943067 creator A5056945892 @default.
• W3082943067 creator A5066226919 @default.
• W3082943067 creator A5066983840 @default.
• W3082943067 creator A5070748632 @default.
• W3082943067 date "2020-12-01" @default.
• W3082943067 modified "2023-10-16" @default.
• W3082943067 title "The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans" @default.
• W3082943067 cites W1012943475 @default.
• W3082943067 cites W1534569692 @default.
• W3082943067 cites W1831144597 @default.
• W3082943067 cites W1854128675 @default.
• W3082943067 cites W1963736913 @default.
• W3082943067 cites W1979518016 @default.
• W3082943067 cites W1982054620 @default.
• W3082943067 cites W1994580609 @default.
• W3082943067 cites W2012601367 @default.
• W3082943067 cites W2026094659 @default.
• W3082943067 cites W2037089067 @default.
• W3082943067 cites W2048165804 @default.
• W3082943067 cites W2050010024 @default.
• W3082943067 cites W2059232568 @default.
• W3082943067 cites W2059650931 @default.
• W3082943067 cites W2064254171 @default.
• W3082943067 cites W2070392079 @default.
• W3082943067 cites W2080809011 @default.
• W3082943067 cites W2097226705 @default.
• W3082943067 cites W2101614441 @default.
• W3082943067 cites W2104756411 @default.
• W3082943067 cites W2113675370 @default.
• W3082943067 cites W2119008756 @default.
• W3082943067 cites W2123739801 @default.
• W3082943067 cites W2128294896 @default.
• W3082943067 cites W2129516277 @default.
• W3082943067 cites W2132957742 @default.
• W3082943067 cites W2133163639 @default.
• W3082943067 cites W2134966009 @default.
• W3082943067 cites W2139174791 @default.
• W3082943067 cites W2151632264 @default.
• W3082943067 cites W2153319633 @default.
• W3082943067 cites W2156494045 @default.
• W3082943067 cites W2157148702 @default.
• W3082943067 cites W2171607710 @default.
• W3082943067 cites W2316740889 @default.
• W3082943067 cites W2552632127 @default.
• W3082943067 cites W2614349964 @default.
• W3082943067 cites W2620629113 @default.
• W3082943067 cites W2624968775 @default.
• W3082943067 cites W2724513016 @default.
• W3082943067 cites W2734994920 @default.
• W3082943067 cites W2736092386 @default.
• W3082943067 cites W2753084136 @default.
• W3082943067 cites W2753588650 @default.
• W3082943067 cites W2782326210 @default.
• W3082943067 cites W2803335400 @default.
• W3082943067 cites W2808182754 @default.
• W3082943067 cites W2884407026 @default.
• W3082943067 cites W2911322073 @default.
• W3082943067 cites W2977063636 @default.
• W3082943067 cites W2977190574 @default.
• W3082943067 cites W2991932877 @default.
• W3082943067 cites W3037693266 @default.
• W3082943067 doi "https://doi.org/10.1016/j.envpol.2020.115568" @default.
• W3082943067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33254717" @default.
• W3082943067 hasPublicationYear "2020" @default.
• W3082943067 type Work @default.
• W3082943067 sameAs 3082943067 @default.
• W3082943067 citedByCount "5" @default.
• W3082943067 countsByYear W30829430672022 @default.
• W3082943067 countsByYear W30829430672023 @default.
• W3082943067 crossrefType "journal-article" @default.
• W3082943067 hasAuthorship W3082943067A5003918874 @default.
• W3082943067 hasAuthorship W3082943067A5008308356 @default.
• W3082943067 hasAuthorship W3082943067A5025172140 @default.
• W3082943067 hasAuthorship W3082943067A5028199089 @default.
• W3082943067 hasAuthorship W3082943067A5030543101 @default.
• W3082943067 hasAuthorship W3082943067A5048307710 @default.
• W3082943067 hasAuthorship W3082943067A5056945892 @default.
• W3082943067 hasAuthorship W3082943067A5066226919 @default.
• W3082943067 hasAuthorship W3082943067A5066983840 @default.
• W3082943067 hasAuthorship W3082943067A5070748632 @default.
• W3082943067 hasConcept C104317684 @default.
• W3082943067 hasConcept C118552586 @default.
• W3082943067 hasConcept C126322002 @default.
• W3082943067 hasConcept C127561419 @default.
• W3082943067 hasConcept C169760540 @default.
• W3082943067 hasConcept C169900460 @default.
• W3082943067 hasConcept C178790620 @default.
• W3082943067 hasConcept C185592680 @default.
• W3082943067 hasConcept C190283241 @default.
• W3082943067 hasConcept C205778803 @default.

• next