FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082969069> ?p ?o ?g. }

• W3082969069 endingPage "e0238316" @default.
• W3082969069 startingPage "e0238316" @default.
• W3082969069 abstract "Background Perinatally HIV-infected children on anti-retroviral treatment (ART) are reported to have metabolic abnormalities such as dyslipidemia, lipodystrophy, and insulin resistance which potentially increase the risk of diabetes, kidney, liver and cardiovascular disease. Objective To elucidate HIV-mediated metabolic complications that sustain even during ART in perinatally HIV-infected children. Method We have carried out metabolic profiling of the plasma of treatment-naïve and ART-suppressed perinatally HIV-infected children and uninfected controls using 1H nuclear magnetic resonance (NMR) spectroscopy followed by statistical analysis and annotation. Result Validated multivariate analysis showed clear distinction among our study groups. Our results showed elevated levels of lactate, glucose, phosphoenolpyruvic acid, propionic acid, 2-ketobutyric acid and tricarboxylic acid (TCA) cycle metabolites in untreated HIV-infected children compared to uninfected controls. ART normalized the levels of several metabolites, however the level of lactate, phosphoenolpyruvic acid, oxoglutaric acid, oxaloacetic acid, myoinositol and glutamine remained upregulated despite ART in HIV-infected children. Pathway analysis revealed perturbed propanoate metabolism, amino acid metabolism, glycolysis and TCA cycle in untreated and ART-suppressed HIV-infected children. Conclusion Developing therapeutic strategies targeting metabolic abnormalities may be beneficial for preventing diabetes, cardiovascular disease or other associated complications in perinatally HIV-infected children." @default.
• W3082969069 created "2020-09-08" @default.
• W3082969069 creator A5008063557 @default.
• W3082969069 creator A5009954093 @default.
• W3082969069 creator A5022449515 @default.
• W3082969069 creator A5023005377 @default.
• W3082969069 creator A5025728332 @default.
• W3082969069 creator A5055393465 @default.
• W3082969069 creator A5059911876 @default.
• W3082969069 date "2020-08-31" @default.
• W3082969069 modified "2023-09-24" @default.
• W3082969069 title "Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy" @default.
• W3082969069 cites W1505655130 @default.
• W3082969069 cites W1582240733 @default.
• W3082969069 cites W1828622309 @default.
• W3082969069 cites W1879288376 @default.
• W3082969069 cites W1963685481 @default.
• W3082969069 cites W1981937271 @default.
• W3082969069 cites W1991855600 @default.
• W3082969069 cites W2010220662 @default.
• W3082969069 cites W2027504173 @default.
• W3082969069 cites W2028685241 @default.
• W3082969069 cites W2036594368 @default.
• W3082969069 cites W2039856595 @default.
• W3082969069 cites W2040538344 @default.
• W3082969069 cites W2052882967 @default.
• W3082969069 cites W2056823758 @default.
• W3082969069 cites W2064769256 @default.
• W3082969069 cites W2071380663 @default.
• W3082969069 cites W2079999658 @default.
• W3082969069 cites W2089532303 @default.
• W3082969069 cites W2092596847 @default.
• W3082969069 cites W2092722618 @default.
• W3082969069 cites W2107131423 @default.
• W3082969069 cites W2109169003 @default.
• W3082969069 cites W2115944543 @default.
• W3082969069 cites W2119665407 @default.
• W3082969069 cites W2124911115 @default.
• W3082969069 cites W2130382164 @default.
• W3082969069 cites W2136500114 @default.
• W3082969069 cites W2141208208 @default.
• W3082969069 cites W2146742006 @default.
• W3082969069 cites W2152344035 @default.
• W3082969069 cites W2153879448 @default.
• W3082969069 cites W2159482845 @default.
• W3082969069 cites W2160063372 @default.
• W3082969069 cites W2221532642 @default.
• W3082969069 cites W2243760265 @default.
• W3082969069 cites W2274628410 @default.
• W3082969069 cites W2317439236 @default.
• W3082969069 cites W2319821009 @default.
• W3082969069 cites W2472395452 @default.
• W3082969069 cites W2517935541 @default.
• W3082969069 cites W2520222164 @default.
• W3082969069 cites W2600254651 @default.
• W3082969069 cites W2613574304 @default.
• W3082969069 cites W2624683527 @default.
• W3082969069 cites W2742723941 @default.
• W3082969069 cites W2769583944 @default.
• W3082969069 cites W2770933533 @default.
• W3082969069 cites W2792134447 @default.
• W3082969069 cites W2808864491 @default.
• W3082969069 cites W2809006732 @default.
• W3082969069 cites W2977620071 @default.
• W3082969069 cites W4256409604 @default.
• W3082969069 doi "https://doi.org/10.1371/journal.pone.0238316" @default.
• W3082969069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7458310" @default.
• W3082969069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32866201" @default.
• W3082969069 hasPublicationYear "2020" @default.
• W3082969069 type Work @default.
• W3082969069 sameAs 3082969069 @default.
• W3082969069 citedByCount "6" @default.
• W3082969069 countsByYear W30829690692021 @default.
• W3082969069 countsByYear W30829690692022 @default.
• W3082969069 countsByYear W30829690692023 @default.
• W3082969069 crossrefType "journal-article" @default.
• W3082969069 hasAuthorship W3082969069A5008063557 @default.
• W3082969069 hasAuthorship W3082969069A5009954093 @default.
• W3082969069 hasAuthorship W3082969069A5022449515 @default.
• W3082969069 hasAuthorship W3082969069A5023005377 @default.
• W3082969069 hasAuthorship W3082969069A5025728332 @default.
• W3082969069 hasAuthorship W3082969069A5055393465 @default.
• W3082969069 hasAuthorship W3082969069A5059911876 @default.
• W3082969069 hasBestOaLocation W30829690691 @default.
• W3082969069 hasConcept C126322002 @default.
• W3082969069 hasConcept C134018914 @default.
• W3082969069 hasConcept C135870905 @default.
• W3082969069 hasConcept C142462285 @default.
• W3082969069 hasConcept C165135838 @default.
• W3082969069 hasConcept C192989942 @default.
• W3082969069 hasConcept C20251656 @default.
• W3082969069 hasConcept C203014093 @default.
• W3082969069 hasConcept C21565614 @default.
• W3082969069 hasConcept C2776441662 @default.
• W3082969069 hasConcept C2777477808 @default.
• W3082969069 hasConcept C2778096610 @default.
• W3082969069 hasConcept C2778160063 @default.
• W3082969069 hasConcept C2779349466 @default.

• next