FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082995854> ?p ?o ?g. }

• W3082995854 abstract "Introduction: Packed red blood cell (PRBC) transfusion in septic shock is generally reserved as a last resort hemodynamic resuscitative measure or for haemoglobin less than 7.0 g/dL. Ex-vivo preservation and storage predispose PRBCs to biochemical / mechanical changes whose impact in a septic host is unknown. This randomised pre-clinical trial specifically evaluates select markers of cardiovascular stress in an ovine model of endotoxemic shock receiving either fresh or stored blood.Methods: Twenty six anesthetised and mechanically ventilated merino ewes were randomly divided into endotoxemic shock (n = 16) or healthy (n = 10) groups. Endotoxemic shock was induced over 4 hours by infusing an escalating dose (total 11.25 mcg / kg) of lipopolysaccharide, LPS (E.coli 055:B5). During the last hour of LPS infusion, 10 mls / kg of either fresh, ≤ 5 days (n = 8) or stored, ≥ 30 days (n = 8) ovine packed PRBCs were administered. Healthy ewes received either fresh, ≤ 5 days (n = 5) or stored, ≥ 30 days (n = 5) ovine PRBCs at corresponding time points. Invasive haemodynamic monitoring and serial echocardiographic assessments were performed in all. Blood samples were measured for cardiac troponin I (cTnI), atrial natriuretic peptide (ANP) and hyaluronan at baseline (T0), 1, 3, 4, 5, 10 and 16h after which the ewes were euthanized.Results: Stored versus fresh PRBCs produced raised hyaluronan levels (P < 0.001) from T3 onwards in both sepsis and healthy groups and resulted in significant (P < 0.001) adverse haemodynamic changes (cardiac index, central venous pressure, pulmonary artery pressure and mixed venous oxygen saturation). Elevated ANP was observed between T3 to T10 (P < 0.001) in septic compared to healthy ewes but there was no association with age of PRBCs. No statistical differences were observed between groups for TnI.Conclusions: Sepsis and storage duration of PRBCs are associated with increased cardiovascular stress suggesting that stored PRBCs may predispose patients with septic shock to poor clinical outcomes." @default.
• W3082995854 created "2020-09-11" @default.
• W3082995854 creator A5001955603 @default.
• W3082995854 creator A5003199987 @default.
• W3082995854 creator A5004994976 @default.
• W3082995854 creator A5005645647 @default.
• W3082995854 creator A5012702628 @default.
• W3082995854 creator A5017751218 @default.
• W3082995854 creator A5019747495 @default.
• W3082995854 creator A5026658421 @default.
• W3082995854 creator A5039887789 @default.
• W3082995854 creator A5042147677 @default.
• W3082995854 creator A5042729842 @default.
• W3082995854 creator A5043407144 @default.
• W3082995854 creator A5047910608 @default.
• W3082995854 creator A5050469350 @default.
• W3082995854 creator A5050826666 @default.
• W3082995854 creator A5054635961 @default.
• W3082995854 creator A5059498904 @default.
• W3082995854 creator A5060191549 @default.
• W3082995854 creator A5066445460 @default.
• W3082995854 creator A5067400459 @default.
• W3082995854 creator A5076816402 @default.
• W3082995854 creator A5090034089 @default.
• W3082995854 date "2018-01-01" @default.
• W3082995854 modified "2023-09-27" @default.
• W3082995854 title "Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation" @default.
• W3082995854 hasPublicationYear "2018" @default.
• W3082995854 type Work @default.
• W3082995854 sameAs 3082995854 @default.
• W3082995854 citedByCount "0" @default.
• W3082995854 crossrefType "journal-article" @default.
• W3082995854 hasAuthorship W3082995854A5001955603 @default.
• W3082995854 hasAuthorship W3082995854A5003199987 @default.
• W3082995854 hasAuthorship W3082995854A5004994976 @default.
• W3082995854 hasAuthorship W3082995854A5005645647 @default.
• W3082995854 hasAuthorship W3082995854A5012702628 @default.
• W3082995854 hasAuthorship W3082995854A5017751218 @default.
• W3082995854 hasAuthorship W3082995854A5019747495 @default.
• W3082995854 hasAuthorship W3082995854A5026658421 @default.
• W3082995854 hasAuthorship W3082995854A5039887789 @default.
• W3082995854 hasAuthorship W3082995854A5042147677 @default.
• W3082995854 hasAuthorship W3082995854A5042729842 @default.
• W3082995854 hasAuthorship W3082995854A5043407144 @default.
• W3082995854 hasAuthorship W3082995854A5047910608 @default.
• W3082995854 hasAuthorship W3082995854A5050469350 @default.
• W3082995854 hasAuthorship W3082995854A5050826666 @default.
• W3082995854 hasAuthorship W3082995854A5054635961 @default.
• W3082995854 hasAuthorship W3082995854A5059498904 @default.
• W3082995854 hasAuthorship W3082995854A5060191549 @default.
• W3082995854 hasAuthorship W3082995854A5066445460 @default.
• W3082995854 hasAuthorship W3082995854A5067400459 @default.
• W3082995854 hasAuthorship W3082995854A5076816402 @default.
• W3082995854 hasAuthorship W3082995854A5090034089 @default.
• W3082995854 hasConcept C126322002 @default.
• W3082995854 hasConcept C178853913 @default.
• W3082995854 hasConcept C2777628635 @default.
• W3082995854 hasConcept C2777953023 @default.
• W3082995854 hasConcept C2778165595 @default.
• W3082995854 hasConcept C2778384902 @default.
• W3082995854 hasConcept C2780014101 @default.
• W3082995854 hasConcept C2780920261 @default.
• W3082995854 hasConcept C2781300812 @default.
• W3082995854 hasConcept C35207712 @default.
• W3082995854 hasConcept C42219234 @default.
• W3082995854 hasConcept C43044207 @default.
• W3082995854 hasConcept C71924100 @default.
• W3082995854 hasConcept C84393581 @default.
• W3082995854 hasConceptScore W3082995854C126322002 @default.
• W3082995854 hasConceptScore W3082995854C178853913 @default.
• W3082995854 hasConceptScore W3082995854C2777628635 @default.
• W3082995854 hasConceptScore W3082995854C2777953023 @default.
• W3082995854 hasConceptScore W3082995854C2778165595 @default.
• W3082995854 hasConceptScore W3082995854C2778384902 @default.
• W3082995854 hasConceptScore W3082995854C2780014101 @default.
• W3082995854 hasConceptScore W3082995854C2780920261 @default.
• W3082995854 hasConceptScore W3082995854C2781300812 @default.
• W3082995854 hasConceptScore W3082995854C35207712 @default.
• W3082995854 hasConceptScore W3082995854C42219234 @default.
• W3082995854 hasConceptScore W3082995854C43044207 @default.
• W3082995854 hasConceptScore W3082995854C71924100 @default.
• W3082995854 hasConceptScore W3082995854C84393581 @default.
• W3082995854 hasLocation W30829958541 @default.
• W3082995854 hasOpenAccess W3082995854 @default.
• W3082995854 hasPrimaryLocation W30829958541 @default.
• W3082995854 hasRelatedWork W135208274 @default.
• W3082995854 hasRelatedWork W1601032365 @default.
• W3082995854 hasRelatedWork W1972179188 @default.
• W3082995854 hasRelatedWork W1978849687 @default.
• W3082995854 hasRelatedWork W2023655934 @default.
• W3082995854 hasRelatedWork W2066153306 @default.
• W3082995854 hasRelatedWork W2071301617 @default.
• W3082995854 hasRelatedWork W2120431099 @default.
• W3082995854 hasRelatedWork W2148037523 @default.
• W3082995854 hasRelatedWork W2353614437 @default.
• W3082995854 hasRelatedWork W2375167214 @default.
• W3082995854 hasRelatedWork W2385066524 @default.
• W3082995854 hasRelatedWork W2396382567 @default.
• W3082995854 hasRelatedWork W2408431677 @default.
• W3082995854 hasRelatedWork W2410867705 @default.

• next