FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083001593> ?p ?o ?g. }

• W3083001593 endingPage "105846" @default.
• W3083001593 startingPage "105846" @default.
• W3083001593 abstract "Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with high morbidity and mortality rates. In spite of numerous advancements have been made in therapeutic methods, the prognosis of HNSCC patients remains poor. Therefore, investigation of crucial genes during HNSCC tumorigenesis which could be exploited as biomarkers and therapeutic targets is greatly needed. In this study, original data of four independent datasets was downloaded from the Gene Expression Omnibus database and analyzed through R language to screen out differentially expressed genes. Paired like homeodomain 1 and SAM and SH3 domain-containing 1 were selected to be further explored through multiple online databases. Quantitative real-time polymerase chain reaction analysis and immunohistochemistry assay were adopted to validate the downregulation of paired like homeodomain 1 and SAM and SH3 domain-containing 1 in HNSCC and statistical analysis indicated their close associations with patient prognosis. In vitro experiments demonstrated the inhibitory effect of paired like homeodomain 1 and SAM and SH3 domain-containing 1 on HNSCC progression. Overall, we identified the aberrant downregulation of paired like homeodomain 1 and SAM and SH3 domain-containing 1 in HNSCC and suggested the potential of utilizing them as therapeutic targets or efficient biomarkers for diagnosis and prognosis evaluation. Our findings may provide novel evidences for the development of new strategies for HNSCC treatment." @default.
• W3083001593 created "2020-09-11" @default.
• W3083001593 creator A5036965952 @default.
• W3083001593 creator A5076501465 @default.
• W3083001593 date "2020-10-01" @default.
• W3083001593 modified "2023-10-13" @default.
• W3083001593 title "Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma" @default.
• W3083001593 cites W1256324905 @default.
• W3083001593 cites W1650797637 @default.
• W3083001593 cites W190488077 @default.
• W3083001593 cites W1963828558 @default.
• W3083001593 cites W1970156673 @default.
• W3083001593 cites W1977918192 @default.
• W3083001593 cites W1980229989 @default.
• W3083001593 cites W1981531386 @default.
• W3083001593 cites W1985843013 @default.
• W3083001593 cites W1996876690 @default.
• W3083001593 cites W2003643844 @default.
• W3083001593 cites W2007987084 @default.
• W3083001593 cites W2014632249 @default.
• W3083001593 cites W2016847420 @default.
• W3083001593 cites W2017777108 @default.
• W3083001593 cites W2020541351 @default.
• W3083001593 cites W2023643669 @default.
• W3083001593 cites W2038855483 @default.
• W3083001593 cites W2056170952 @default.
• W3083001593 cites W2070097483 @default.
• W3083001593 cites W2083991264 @default.
• W3083001593 cites W2087022716 @default.
• W3083001593 cites W2087810003 @default.
• W3083001593 cites W2093255090 @default.
• W3083001593 cites W2102088808 @default.
• W3083001593 cites W2115591535 @default.
• W3083001593 cites W2148028028 @default.
• W3083001593 cites W2167126357 @default.
• W3083001593 cites W2244015304 @default.
• W3083001593 cites W2371793545 @default.
• W3083001593 cites W2390584831 @default.
• W3083001593 cites W2513817125 @default.
• W3083001593 cites W2514327571 @default.
• W3083001593 cites W2517503832 @default.
• W3083001593 cites W2531927615 @default.
• W3083001593 cites W2560322684 @default.
• W3083001593 cites W2607129810 @default.
• W3083001593 cites W2608913686 @default.
• W3083001593 cites W2614544466 @default.
• W3083001593 cites W2618013004 @default.
• W3083001593 cites W2621579942 @default.
• W3083001593 cites W2781525129 @default.
• W3083001593 cites W2781659254 @default.
• W3083001593 cites W2890984424 @default.
• W3083001593 cites W2892585921 @default.
• W3083001593 cites W2899959130 @default.
• W3083001593 cites W2911675656 @default.
• W3083001593 cites W4240331705 @default.
• W3083001593 doi "https://doi.org/10.1016/j.biocel.2020.105846" @default.
• W3083001593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32905855" @default.
• W3083001593 hasPublicationYear "2020" @default.
• W3083001593 type Work @default.
• W3083001593 sameAs 3083001593 @default.
• W3083001593 citedByCount "4" @default.
• W3083001593 countsByYear W30830015932021 @default.
• W3083001593 countsByYear W30830015932023 @default.
• W3083001593 crossrefType "journal-article" @default.
• W3083001593 hasAuthorship W3083001593A5036965952 @default.
• W3083001593 hasAuthorship W3083001593A5076501465 @default.
• W3083001593 hasConcept C104317684 @default.
• W3083001593 hasConcept C121587040 @default.
• W3083001593 hasConcept C121608353 @default.
• W3083001593 hasConcept C126322002 @default.
• W3083001593 hasConcept C127561419 @default.
• W3083001593 hasConcept C143998085 @default.
• W3083001593 hasConcept C150194340 @default.
• W3083001593 hasConcept C204232928 @default.
• W3083001593 hasConcept C2776530083 @default.
• W3083001593 hasConcept C2776833033 @default.
• W3083001593 hasConcept C2779399171 @default.
• W3083001593 hasConcept C502942594 @default.
• W3083001593 hasConcept C54355233 @default.
• W3083001593 hasConcept C555283112 @default.
• W3083001593 hasConcept C60644358 @default.
• W3083001593 hasConcept C71924100 @default.
• W3083001593 hasConcept C86803240 @default.
• W3083001593 hasConceptScore W3083001593C104317684 @default.
• W3083001593 hasConceptScore W3083001593C121587040 @default.
• W3083001593 hasConceptScore W3083001593C121608353 @default.
• W3083001593 hasConceptScore W3083001593C126322002 @default.
• W3083001593 hasConceptScore W3083001593C127561419 @default.
• W3083001593 hasConceptScore W3083001593C143998085 @default.
• W3083001593 hasConceptScore W3083001593C150194340 @default.
• W3083001593 hasConceptScore W3083001593C204232928 @default.
• W3083001593 hasConceptScore W3083001593C2776530083 @default.
• W3083001593 hasConceptScore W3083001593C2776833033 @default.
• W3083001593 hasConceptScore W3083001593C2779399171 @default.
• W3083001593 hasConceptScore W3083001593C502942594 @default.
• W3083001593 hasConceptScore W3083001593C54355233 @default.
• W3083001593 hasConceptScore W3083001593C555283112 @default.
• W3083001593 hasConceptScore W3083001593C60644358 @default.

• next