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- W3083017800 abstract "ABSTRACT Mother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk transmission, an exploratory study was designed to apply next generation sequencing and a custom bioinformatics pipeline for HIV-1 gp41 extending from heptad repeat region 2 (HR2) through the membrane proximal external region (MPER) and the membrane spanning domain (MSD). Viral populations during pregnancy from women who transmitted by breastfeeding, compared to those who did not, displayed greater biodiversity, more frequent amino acid polymorphisms, lower hydropathy index and greater positive charge. Viral characteristics were restricted to MPER, failed to extend into flanking HR2 or MSD regions, and were unrelated to predicted neutralization resistance. Findings provide novel parameters to evaluate an association between maternal MPER variants present during gestation and lactogenesis with subsequent transmission outcomes by breastfeeding. IMPORTANCE HIV-1 transmission through breastfeeding accounts for 39% of MTCT and continues as a major route of pediatric infection in developing countries where access to interventions for interrupting transmission is limited. Identifying women who are likely to transmit during breastfeeding would focus therapies during the breastfeeding period to reduce MTCT. Findings from our pilot study identify novel characteristics of gestational viral MPER quasispecies related to transmission outcomes and raise the possibility for predicting MTCT by breastfeeding based on identifying mothers with high-risk viral populations." @default.
- W3083017800 created "2020-09-11" @default.
- W3083017800 creator A5000314616 @default.
- W3083017800 creator A5006990949 @default.
- W3083017800 creator A5009242675 @default.
- W3083017800 creator A5037335831 @default.
- W3083017800 creator A5065078265 @default.
- W3083017800 creator A5073718294 @default.
- W3083017800 date "2020-09-08" @default.
- W3083017800 modified "2023-10-14" @default.
- W3083017800 title "Unique Genotypic Features of HIV-1 C Gp41 Membrane Proximal External Region Variants during Pregnancy Relate to Mother-to-child Transmission via Breastfeeding" @default.
- W3083017800 cites W1963999282 @default.
- W3083017800 cites W1964937304 @default.
- W3083017800 cites W1965346800 @default.
- W3083017800 cites W1969035202 @default.
- W3083017800 cites W1969693189 @default.
- W3083017800 cites W1971432176 @default.
- W3083017800 cites W197295974 @default.
- W3083017800 cites W1975304761 @default.
- W3083017800 cites W1987999246 @default.
- W3083017800 cites W1989215494 @default.
- W3083017800 cites W1989733975 @default.
- W3083017800 cites W1990751802 @default.
- W3083017800 cites W1991572753 @default.
- W3083017800 cites W1992523293 @default.
- W3083017800 cites W1996113096 @default.
- W3083017800 cites W1996905173 @default.
- W3083017800 cites W1997036689 @default.
- W3083017800 cites W2000016596 @default.
- W3083017800 cites W2000855786 @default.
- W3083017800 cites W2001989473 @default.
- W3083017800 cites W2004148753 @default.
- W3083017800 cites W2004601480 @default.
- W3083017800 cites W2010277487 @default.
- W3083017800 cites W2012036886 @default.
- W3083017800 cites W2018678242 @default.
- W3083017800 cites W2019004051 @default.
- W3083017800 cites W2022738774 @default.
- W3083017800 cites W2023434411 @default.
- W3083017800 cites W2025299059 @default.
- W3083017800 cites W2025380347 @default.
- W3083017800 cites W2029928145 @default.
- W3083017800 cites W2030017358 @default.
- W3083017800 cites W2034981907 @default.
- W3083017800 cites W2036549279 @default.
- W3083017800 cites W2039634981 @default.
- W3083017800 cites W2040889536 @default.
- W3083017800 cites W2054017667 @default.
- W3083017800 cites W2058625457 @default.
- W3083017800 cites W2058632331 @default.
- W3083017800 cites W2060253881 @default.
- W3083017800 cites W2061533648 @default.
- W3083017800 cites W2065140768 @default.
- W3083017800 cites W2066295706 @default.
- W3083017800 cites W2069368224 @default.
- W3083017800 cites W2069370553 @default.
- W3083017800 cites W2070086938 @default.
- W3083017800 cites W2071521826 @default.
- W3083017800 cites W2073548709 @default.
- W3083017800 cites W2079184247 @default.
- W3083017800 cites W2081081018 @default.
- W3083017800 cites W2081390388 @default.
- W3083017800 cites W2083391421 @default.
- W3083017800 cites W2084197987 @default.
- W3083017800 cites W2097948558 @default.
- W3083017800 cites W2106197125 @default.
- W3083017800 cites W2107167366 @default.
- W3083017800 cites W2107916369 @default.
- W3083017800 cites W2109229894 @default.
- W3083017800 cites W2109957081 @default.
- W3083017800 cites W2110499527 @default.
- W3083017800 cites W2112891242 @default.
- W3083017800 cites W2118166920 @default.
- W3083017800 cites W2119632499 @default.
- W3083017800 cites W2125962158 @default.
- W3083017800 cites W2127072493 @default.
- W3083017800 cites W2132632499 @default.
- W3083017800 cites W2135691292 @default.
- W3083017800 cites W2137054560 @default.
- W3083017800 cites W2138525755 @default.
- W3083017800 cites W2139696773 @default.
- W3083017800 cites W2139915966 @default.
- W3083017800 cites W2145351976 @default.
- W3083017800 cites W2145458131 @default.
- W3083017800 cites W2145661359 @default.
- W3083017800 cites W2146672876 @default.
- W3083017800 cites W2148245437 @default.
- W3083017800 cites W2148929632 @default.
- W3083017800 cites W2152283056 @default.
- W3083017800 cites W2152881035 @default.
- W3083017800 cites W2157784706 @default.
- W3083017800 cites W2158266834 @default.
- W3083017800 cites W2162885017 @default.
- W3083017800 cites W2164723930 @default.
- W3083017800 cites W2167278513 @default.
- W3083017800 cites W2167594767 @default.
- W3083017800 cites W2170595655 @default.
- W3083017800 cites W2170830827 @default.
- W3083017800 cites W3216088338 @default.
- W3083017800 cites W4250986973 @default.