FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083060993> ?p ?o ?g. }

• W3083060993 endingPage "6577" @default.
• W3083060993 startingPage "6563" @default.
• W3083060993 abstract "Developmental dysplasia of the hip (DDH) can increase the pressure between the joints, which causes secondary hip osteoarthritis. The aim of the present study was to fabricate poly(D, L-lactic acid)-poly(ethylene glycol)-poly(D, L-lactic acid) (PELA) electrospun fibrous scaffolds, immobilized with bone morphogenetic protein-2 (BMP-2), to repair the acetabulum defects.The characteristics of PELA electrospun were analyzed using scanning electron microscopy, the release kinetics of BMP-2 in vitro were analyzed using enzyme-linked immunosorbent assays. Human mesenchymal stem cells (hMSCs) were used for in vitro experiments, the biocompatibility of the electrospinning materials was investigated using a cell counting kit-8 (CCK-8) kit, and osteogenic differentiation was tested via alkaline phosphatase (ALP) activity and relative gene expression. Eighteen miniature pig animal models were used in the in vivo experiment. The pigs were sacrificed at 24 weeks after surgery, and the reconstructed acetabulum was evaluated using histological sections.Structural analysis revealed that the diameter of the PELA electrospun fiber was 0.8195 ± 0.16 μm. The PELA electrospun fiber materials showed good hydrophilicity and biocompatibility and could continuously release BMP-2 within 27 days: 16.07 ± 0.11 ng of BMP-2 was released from the scaffold. A total of sixteen implants fully filled the defects, and hematoxylin and eosin staining and Goldner's trichrome staining showed that the simple tendon group (T group) was mostly fibrous tissues, lots of fibroblasts and small amounts of chondrocytes were observed in the polydopamine-coated electrospun fiber group (DP group). The DP plus BMP-2 (DPB) group showed a large number of chondrocytes and partial new bone tissues.PELA electrospun fibrous scaffolds are good sustained-release carriers, which can not only induce implant differentiation into cartilage and bone but also are completely degraded without toxicity. Therefore, the material can be used for bone and cartilage regeneration." @default.
• W3083060993 created "2020-09-11" @default.
• W3083060993 creator A5005639960 @default.
• W3083060993 creator A5029852350 @default.
• W3083060993 creator A5038532060 @default.
• W3083060993 date "2020-09-01" @default.
• W3083060993 modified "2023-10-13" @default.
• W3083060993 title "<p>Electrospun Fibers Immobilized with BMP-2 Mediated by Polydopamine Combined with Autogenous Tendon to Repair Developmental Dysplasia of the Hip in a Porcine Model</p>" @default.
• W3083060993 cites W11818958 @default.
• W3083060993 cites W1536592659 @default.
• W3083060993 cites W1862977572 @default.
• W3083060993 cites W1964756829 @default.
• W3083060993 cites W1973016661 @default.
• W3083060993 cites W1977214686 @default.
• W3083060993 cites W2015315468 @default.
• W3083060993 cites W2042258668 @default.
• W3083060993 cites W2047515882 @default.
• W3083060993 cites W2054409347 @default.
• W3083060993 cites W2072922381 @default.
• W3083060993 cites W2092235945 @default.
• W3083060993 cites W2095339543 @default.
• W3083060993 cites W2098249388 @default.
• W3083060993 cites W2119838587 @default.
• W3083060993 cites W2125728570 @default.
• W3083060993 cites W2138267337 @default.
• W3083060993 cites W2142042941 @default.
• W3083060993 cites W2202603970 @default.
• W3083060993 cites W2261888464 @default.
• W3083060993 cites W2283490245 @default.
• W3083060993 cites W2319860567 @default.
• W3083060993 cites W2336234561 @default.
• W3083060993 cites W2509043347 @default.
• W3083060993 cites W2553960461 @default.
• W3083060993 cites W2571334155 @default.
• W3083060993 cites W2571386242 @default.
• W3083060993 cites W2738683587 @default.
• W3083060993 cites W2766527733 @default.
• W3083060993 cites W2766790235 @default.
• W3083060993 cites W2771140022 @default.
• W3083060993 cites W2809292241 @default.
• W3083060993 cites W2889000775 @default.
• W3083060993 cites W2891971827 @default.
• W3083060993 cites W2923932023 @default.
• W3083060993 cites W2953441276 @default.
• W3083060993 cites W2981074407 @default.
• W3083060993 doi "https://doi.org/10.2147/ijn.s259028" @default.
• W3083060993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7490068" @default.
• W3083060993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32982218" @default.
• W3083060993 hasPublicationYear "2020" @default.
• W3083060993 type Work @default.
• W3083060993 sameAs 3083060993 @default.
• W3083060993 citedByCount "13" @default.
• W3083060993 countsByYear W30830609932021 @default.
• W3083060993 countsByYear W30830609932022 @default.
• W3083060993 countsByYear W30830609932023 @default.
• W3083060993 crossrefType "journal-article" @default.
• W3083060993 hasAuthorship W3083060993A5005639960 @default.
• W3083060993 hasAuthorship W3083060993A5029852350 @default.
• W3083060993 hasAuthorship W3083060993A5038532060 @default.
• W3083060993 hasBestOaLocation W30830609931 @default.
• W3083060993 hasConcept C136229726 @default.
• W3083060993 hasConcept C142724271 @default.
• W3083060993 hasConcept C144796933 @default.
• W3083060993 hasConcept C150903083 @default.
• W3083060993 hasConcept C160160445 @default.
• W3083060993 hasConcept C163031210 @default.
• W3083060993 hasConcept C178790620 @default.
• W3083060993 hasConcept C181199279 @default.
• W3083060993 hasConcept C185592680 @default.
• W3083060993 hasConcept C198826908 @default.
• W3083060993 hasConcept C202751555 @default.
• W3083060993 hasConcept C207001950 @default.
• W3083060993 hasConcept C2777230088 @default.
• W3083060993 hasConcept C30352789 @default.
• W3083060993 hasConcept C49892992 @default.
• W3083060993 hasConcept C521977710 @default.
• W3083060993 hasConcept C55493867 @default.
• W3083060993 hasConcept C71924100 @default.
• W3083060993 hasConcept C74864618 @default.
• W3083060993 hasConcept C86803240 @default.
• W3083060993 hasConceptScore W3083060993C136229726 @default.
• W3083060993 hasConceptScore W3083060993C142724271 @default.
• W3083060993 hasConceptScore W3083060993C144796933 @default.
• W3083060993 hasConceptScore W3083060993C150903083 @default.
• W3083060993 hasConceptScore W3083060993C160160445 @default.
• W3083060993 hasConceptScore W3083060993C163031210 @default.
• W3083060993 hasConceptScore W3083060993C178790620 @default.
• W3083060993 hasConceptScore W3083060993C181199279 @default.
• W3083060993 hasConceptScore W3083060993C185592680 @default.
• W3083060993 hasConceptScore W3083060993C198826908 @default.
• W3083060993 hasConceptScore W3083060993C202751555 @default.
• W3083060993 hasConceptScore W3083060993C207001950 @default.
• W3083060993 hasConceptScore W3083060993C2777230088 @default.
• W3083060993 hasConceptScore W3083060993C30352789 @default.
• W3083060993 hasConceptScore W3083060993C49892992 @default.
• W3083060993 hasConceptScore W3083060993C521977710 @default.
• W3083060993 hasConceptScore W3083060993C55493867 @default.
• W3083060993 hasConceptScore W3083060993C71924100 @default.

• next