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- W3083069046 abstract "To observe the influence of excessive fluoride on the levels of osteocalcin and testosterone in the testis of the male mouse.Twenty-four C57BL/6J male mice were equally randomized into a normal control and a fluorosis model group, the former fed on distilled water while the latter on a solution of sodium fluoride (100 mg/L) in distilled water, both for 12 weeks. Then, the level of osteocalcin in the testis tissue was measured with the immunohistochemical streptavidin-peroxidase (SP) method and those of osteocalcin and testosterone in the serum determined by ELISA.After 12 weeks of fluoride intervention, the level of serum osteocalcin was significantly higher in the fluorosis models than in the normal controls (［68.05 ± 5.32］ vs ［47.50 ± 5.73］ pg/mL, F = 11.901, P = 0.008), while that of testosterone markedly lower in the former than the latter group (［8.07 ± 1.35］ vs ［12.94 ± 3.09］ ng/mL, F = 2.313, P = 0.006). The results of immunohistochemical SP showed the expression of osteocalcin in the cell membrane and cytoplasm of the fluorosis models, which was evidently higher than in the normal controls.Twelve-week intake of 100 mg/L fluoride solution can decrease the level of testosterone and increase the expression of osteocalcin in the testis of the male mouse.目的： 观察过量氟对小鼠睾丸中骨钙素(OCN)的影响及睾酮(T)水平的变化。方法: 选取24只C57 black 6J(C57BL/6J)雄性小鼠，随机分为两组（正常组12只，氟干预组12只），正常组饮用蒸馏水，氟干预组饮用100 mg/L氟化钠溶液，自由饮用3个月，制备氟中毒模型，采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连结法（SP）,定位检测小鼠睾丸组织中OCN的表达采用酶联免疫吸附法（ELISA），检测血清中OCN及T水平的变化。结果: 氟干预组小鼠血清中OCN水平明显高于对照组（F=11.901，P=0.008），氟干预组小鼠T分泌量明显低于对照组睾酮（F=2.313，P=0.006），免疫组化结果显示氟干预组OCN表达在细胞膜和细胞质，且阳性表达强于对照组。结论： 饮用100 mg/L含氟水3个月能够导致雄性小鼠的T降低，睾丸中OCN水平表达升高。." @default.
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- W3083069046 date "2017-09-01" @default.
- W3083069046 modified "2023-09-27" @default.
- W3083069046 title "[Excessive fluoride increases the expression of osteocalcin in the mouse testis]." @default.
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