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- W3083080034 endingPage "23625" @default.
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- W3083080034 abstract "Significance The mTORC1 complex provides a critical role in cell function, regulating a variety of processes including growth and autophagy. mTORC1 signaling is hyperactivated in a range of common diseases including cancer, epilepsy, and neurodegenerative disorders. Hence, mTORC1 signaling provides an important target for regulation in many contexts. Here, we show that decanoic acid, a key component of a widely used medicinal diet, reduces mTORC1 activity. We identify this in a tractable model system, and validate it in ex vivo rat brain tissue and in human iPSC-derived astrocytes from patients with a clinically relevant disease. Thus, we provide insight into an easily accessible therapeutic approach for a range of diseases." @default.
- W3083080034 created "2020-09-11" @default.
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- W3083080034 date "2020-09-02" @default.
- W3083080034 modified "2023-10-14" @default.
- W3083080034 title "Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling" @default.
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- W3083080034 doi "https://doi.org/10.1073/pnas.2008980117" @default.
- W3083080034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7519326" @default.
- W3083080034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32879008" @default.
- W3083080034 hasPublicationYear "2020" @default.
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