FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083157088> ?p ?o ?g. }

• W3083157088 endingPage "6510" @default.
• W3083157088 startingPage "6510" @default.
• W3083157088 abstract "Organophosphorus (OP) compounds are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment. Thus, investigations with reactivators have been deeply developed in order to design new antidotes with better efficiency, as well as a greater spectrum of action in the acetylcholinesterase (AChE) reactivation process. With that in mind, in this work, we investigated the behavior of trimedoxime toward the Mus musculus acetylcholinesterase (MmAChE) inhibited by a range of nerve agents, such as chemical weapons. From experimental assays, reactivation percentages were obtained for the reactivation of different AChE–OP complexes. On the other hand, theoretical calculations were performed to assess the differences in interaction modes and the reactivity of trimedoxime within the AChE active site. Comparing theoretical and experimental data, it is possible to notice that the oxime, in most cases, showed better reactivation percentages at higher concentrations, with the best result for the reactivation of the AChE–VX adduct. From this work, it was revealed that the mechanistic process contributes most to the oxime efficiency than the interaction in the site. In this way, this study is important to better understand the reactivation process through trimedoxime, contributing to the proposal of novel antidotes." @default.
• W3083157088 created "2020-09-11" @default.
• W3083157088 creator A5004074361 @default.
• W3083157088 creator A5013987157 @default.
• W3083157088 creator A5060472134 @default.
• W3083157088 creator A5065396995 @default.
• W3083157088 creator A5065996254 @default.
• W3083157088 creator A5066903927 @default.
• W3083157088 creator A5076775419 @default.
• W3083157088 date "2020-09-05" @default.
• W3083157088 modified "2023-10-16" @default.
• W3083157088 title "Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects" @default.
• W3083157088 cites W1128548427 @default.
• W3083157088 cites W1969456011 @default.
• W3083157088 cites W1969656407 @default.
• W3083157088 cites W1970262488 @default.
• W3083157088 cites W1981640621 @default.
• W3083157088 cites W2010322744 @default.
• W3083157088 cites W2014921342 @default.
• W3083157088 cites W2015212841 @default.
• W3083157088 cites W2016651377 @default.
• W3083157088 cites W2024684631 @default.
• W3083157088 cites W2042237171 @default.
• W3083157088 cites W2043855224 @default.
• W3083157088 cites W2055798187 @default.
• W3083157088 cites W2065633462 @default.
• W3083157088 cites W2084391182 @default.
• W3083157088 cites W2091745160 @default.
• W3083157088 cites W2102537419 @default.
• W3083157088 cites W2107029002 @default.
• W3083157088 cites W2114102865 @default.
• W3083157088 cites W2120741921 @default.
• W3083157088 cites W2121055704 @default.
• W3083157088 cites W2135028070 @default.
• W3083157088 cites W2140132200 @default.
• W3083157088 cites W2140999447 @default.
• W3083157088 cites W2142564846 @default.
• W3083157088 cites W2153419090 @default.
• W3083157088 cites W2158355140 @default.
• W3083157088 cites W2160281312 @default.
• W3083157088 cites W2294114693 @default.
• W3083157088 cites W2338860998 @default.
• W3083157088 cites W2468164240 @default.
• W3083157088 cites W2507726162 @default.
• W3083157088 cites W2562174328 @default.
• W3083157088 cites W2584918366 @default.
• W3083157088 cites W2655432163 @default.
• W3083157088 cites W2736358156 @default.
• W3083157088 cites W2760197992 @default.
• W3083157088 cites W2794969988 @default.
• W3083157088 cites W2887081833 @default.
• W3083157088 cites W2945232470 @default.
• W3083157088 cites W2947613489 @default.
• W3083157088 cites W2949160861 @default.
• W3083157088 cites W3002928708 @default.
• W3083157088 cites W3010835548 @default.
• W3083157088 cites W3033401203 @default.
• W3083157088 doi "https://doi.org/10.3390/ijms21186510" @default.
• W3083157088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7554915" @default.
• W3083157088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32899591" @default.
• W3083157088 hasPublicationYear "2020" @default.
• W3083157088 type Work @default.
• W3083157088 sameAs 3083157088 @default.
• W3083157088 citedByCount "1" @default.
• W3083157088 countsByYear W30831570882021 @default.
• W3083157088 crossrefType "journal-article" @default.
• W3083157088 hasAuthorship W3083157088A5004074361 @default.
• W3083157088 hasAuthorship W3083157088A5013987157 @default.
• W3083157088 hasAuthorship W3083157088A5060472134 @default.
• W3083157088 hasAuthorship W3083157088A5065396995 @default.
• W3083157088 hasAuthorship W3083157088A5065996254 @default.
• W3083157088 hasAuthorship W3083157088A5066903927 @default.
• W3083157088 hasAuthorship W3083157088A5076775419 @default.
• W3083157088 hasBestOaLocation W30831570881 @default.
• W3083157088 hasConcept C142724271 @default.
• W3083157088 hasConcept C181199279 @default.
• W3083157088 hasConcept C185592680 @default.
• W3083157088 hasConcept C204787440 @default.
• W3083157088 hasConcept C2776130705 @default.
• W3083157088 hasConcept C2776910235 @default.
• W3083157088 hasConcept C2778706303 @default.
• W3083157088 hasConcept C2778816929 @default.
• W3083157088 hasConcept C2779059548 @default.
• W3083157088 hasConcept C2779648554 @default.
• W3083157088 hasConcept C55493867 @default.
• W3083157088 hasConcept C71240020 @default.
• W3083157088 hasConcept C71924100 @default.
• W3083157088 hasConcept C86803240 @default.
• W3083157088 hasConcept C98274493 @default.
• W3083157088 hasConceptScore W3083157088C142724271 @default.
• W3083157088 hasConceptScore W3083157088C181199279 @default.
• W3083157088 hasConceptScore W3083157088C185592680 @default.
• W3083157088 hasConceptScore W3083157088C204787440 @default.
• W3083157088 hasConceptScore W3083157088C2776130705 @default.
• W3083157088 hasConceptScore W3083157088C2776910235 @default.
• W3083157088 hasConceptScore W3083157088C2778706303 @default.
• W3083157088 hasConceptScore W3083157088C2778816929 @default.
• W3083157088 hasConceptScore W3083157088C2779059548 @default.

• next