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- W3083194800 abstract "Purpose: Weight loss is common among patients with squamous cell carcinoma of the head and neck during chemo-radiotherapy and may be due to multiple tumor and treatment related factors. The aim of the present study was to evaluate factors associated with weight loss during radiotherapy treatment of head and neck cancers.Methods: One hundred one patients of squamous cell carcinoma of head and neck treated with concurrent chemoradiation or postoperative radiotherapy were evaluated in this analysis. Major head and neck subsites including Oropharynx, Oral cavity Hypopharynx and Nasopharynx were included in the analysis. A dose of 66-70Gy was given in the radical chemoradiation schedule. In postoperative radiotherapy, a dose of 60-64Gy was delivered. Patients were treated with two-field or three field conventional radiation techniques. Patient’s weight was evaluated before, weekly during treatment and after completion of treatment to evaluate weight loss trends. Weight loss grading was done as per CTCAE v3.Results: Analysis was done to see which factors were causative in patients having a grade 1(5-10%) and grade 2(>10%) weight loss. Three variables were found to be significant for >5% weight loss. These were a tumor located in base of tongue (p 60 Gy (p<0.012). Other factors like trismus (p<0.063) and xerostomia (p<0.060) also showed trend towards significance. No difference was observed in patients with weekly or 3 weekly chemo-radiation schedules. Conclusion: Our study shows that base of tongue cancers on chemoradiation had significant weight loss compared to other head and neck subsites. Radiation doses over 60 Gy is another significant factor for weight loss." @default.
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- W3083194800 date "2019-01-01" @default.
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- W3083194800 title "Evaluation of Treatment Related Weight Loss in Patients with Head and Neck Cancers Undergoing Radiotherapy" @default.
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