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• W3083227365 abstract "Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear.We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models of diet-induced obesity and CVD.Eight-week-old C57BL/6J wild-type (WT) and LDLr-/-ApoB100/100 (LRKO) male mice were fed for 12 and 24 wk, respectively, with a high-fat/high-sucrose diet [66% kcal lipids, 22% kcal carbohydrates (100% sucrose), 12% kcal proteins]. The protein sources of the 4 diets were 100% nondairy protein (NDP), or 50% of the NDP energy replaced by milk (MP), milk fermented by Lactobacillus helveticus (FMP), or Greek-style yogurt (YP) protein. Fecal 16S rRNA gene-based amplicon sequencing, intestinal gene expression, and glucose tolerance test were conducted. Hepatic inflammation and circulating adhesion molecules were measured by multiplex assays.Feeding WT mice for 12 wk led to a 74% increase in body weight, whereas after 24 wk the LRKO mice had a 101.5% increase compared with initial body weight. Compared with NDP and MP, the consumption of FMP and YP modulated the gut microbiota composition in a similar clustering pattern, upregulating the Streptococcus genus in both genotypes. In WT mice, feeding YP compared with NDP increased the expression of genes involved in jejunal (Reg3b, 7.3-fold, P = 0.049) and ileal (Ocln, 1.7-fold, P = 0.047; Il1-β,1.7-fold, P = 0.038; Nos2, 3.8-fold, P = 0.018) immunity and integrity. In LRKO mice, feeding YP compared with MP improved insulin sensitivity by 65% (P = 0.039). In LRKO mice, feeding with FMP versus NDP attenuated hepatic inflammation (monocyte chemoattractant protein 1, 2.1-fold, P ˂ 0.0001; IL1-β, 5.7-fold, P = 0.0003; INF-γ, 1.7-fold, P = 0.002) whereas both FMP [vascular adhesion molecule 1 (VCAM1), 1.3-fold, P = 0.0003] and YP (VCAM1, 1.04-fold, P = 0.013; intracellular adhesion molecule 1, 1.4-fold, P = 0.028) decreased circulating adhesion molecules.Both fermented dairy protein products reduce cardiometabolic risk factors in diet-induced obese mice, possibly by modulating the gut microbiota." @default.
• W3083227365 created "2020-09-11" @default.
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• W3083227365 date "2020-10-01" @default.
• W3083227365 modified "2023-10-17" @default.
• W3083227365 title "Distinct Effects of Milk-Derived and Fermented Dairy Protein on Gut Microbiota and Cardiometabolic Markers in Diet-Induced Obese Mice" @default.
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• W3083227365 cites W1986142882 @default.
• W3083227365 cites W1988440349 @default.
• W3083227365 cites W1996656783 @default.
• W3083227365 cites W2001478301 @default.
• W3083227365 cites W2011299536 @default.
• W3083227365 cites W2034285706 @default.
• W3083227365 cites W2036897871 @default.
• W3083227365 cites W2038463091 @default.
• W3083227365 cites W2044995312 @default.
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• W3083227365 cites W2053494703 @default.
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• W3083227365 cites W2068140733 @default.
• W3083227365 cites W2077072558 @default.
• W3083227365 cites W2083403064 @default.
• W3083227365 cites W2086648828 @default.
• W3083227365 cites W2093492347 @default.
• W3083227365 cites W2094306515 @default.
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• W3083227365 cites W2152885278 @default.
• W3083227365 cites W2156738322 @default.
• W3083227365 cites W2160517070 @default.
• W3083227365 cites W2168526937 @default.
• W3083227365 cites W2186479083 @default.
• W3083227365 cites W2217799239 @default.
• W3083227365 cites W2226817873 @default.
• W3083227365 cites W2254203293 @default.
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• W3083227365 cites W2282190131 @default.
• W3083227365 cites W2401404581 @default.
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• W3083227365 cites W2784040850 @default.
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• W3083227365 doi "https://doi.org/10.1093/jn/nxaa217" @default.
• W3083227365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7549311" @default.
• W3083227365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32886125" @default.
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