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- W3083238304 abstract "Childhood maltreatment, which can take the form of physical or psychological abuse, is experienced by more than a quarter of all children. Early life stress has substantial and long-term consequences, including an increased risk of drug abuse and psychiatric disorders in adolescence and adulthood, and this risk is higher in women than in men. The neuronal mechanisms underlying the influence of early life adversities on brain functioning remain poorly understood; therefore, in the current study, we used maternal separation (MS), a rodent model of early-life neglect, to verify its influence on the properties of neurons in the ventral tegmental area (VTA), a brain area critically involved in reward and motivation processing. Using whole-cell patch-clamp recordings in brain slices from adolescent female Sprague-Dawley rats, we found an MS-induced increase in the excitability of putative dopaminergic (DAergic) neurons selectively in the medial part of the VTA. We also showed an enhancement of excitatory synaptic transmission in VTA putative DAergic neurons. MS-induced alterations in electrophysiology were accompanied by an increase in the diameter of dendritic spine heads on lateral VTA DAergic neurons, although the overall dendritic spine density remained unchanged. Finally, we reported MS-related increases in basal plasma ACTH and corticosterone levels. These results show the long-term consequences of early life stress and indicate the possible neuronal mechanisms of behavioral disturbances in individuals who experience early life neglect." @default.
- W3083238304 created "2020-09-11" @default.
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- W3083238304 date "2020-11-01" @default.
- W3083238304 modified "2023-10-15" @default.
- W3083238304 title "Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats" @default.
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- W3083238304 doi "https://doi.org/10.1016/j.ynstr.2020.100250" @default.
- W3083238304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7739067" @default.
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