FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083258145> ?p ?o ?g. }

• W3083258145 endingPage "2066" @default.
• W3083258145 startingPage "2052" @default.
• W3083258145 abstract "Sulfonamides have been in clinical use for many years, and the development of bioactive substances containing the sulfonamide subunit has grown steadily in view of their important biological properties such as antibacterial, antifungal, antiparasitic, antioxidant, and antitumour properties. This review addresses the medicinal chemistry aspects of sulfonamides; covering their discovery, the structure- activity relationship and the mechanism of action of the antibacterial sulfonamide class, as well as the physico-chemical and pharmacological properties associated with this class. It also provides an overview of the various biological activities inherent to sulfonamides, reporting research that emphasises the importance of this group in the planning and development of bioactive substances, with a special focus on potential antitumour properties. The synthesis of sulfonamides is considered to be simple and provides a diversity of derivatives from a wide variety of amines and sulfonyl chlorides. The sulfonamide group is a non-classical bioisostere of carboxyl groups, phenolic hydroxyl groups and amide groups. This review highlights that most of the bioactive substances have the sulfonamide group, or a related group such as sulfonylurea, in an orientation towards other functional groups. This structural characteristic was observed in molecules with distinct antibacterial activities, demonstrating a clear structure-activity relationship of sulfonamides. This short review sought to contextualise the discovery of classic antibacterial sulfonamides and their physico-chemical and pharmacological properties. The importance of the sulfonamide subunit in Medicinal Chemistry has been highlighted and emphasised, in order to promote its inclusion in the planning and synthesis of future drugs." @default.
• W3083258145 created "2020-09-11" @default.
• W3083258145 creator A5003478673 @default.
• W3083258145 creator A5017259129 @default.
• W3083258145 creator A5023548070 @default.
• W3083258145 creator A5080470559 @default.
• W3083258145 creator A5085167439 @default.
• W3083258145 date "2020-12-28" @default.
• W3083258145 modified "2023-10-17" @default.
• W3083258145 title "From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides" @default.
• W3083258145 cites W1524278639 @default.
• W3083258145 cites W1652310094 @default.
• W3083258145 cites W1964219047 @default.
• W3083258145 cites W1964719327 @default.
• W3083258145 cites W1966319322 @default.
• W3083258145 cites W1974947009 @default.
• W3083258145 cites W1975947882 @default.
• W3083258145 cites W1979777524 @default.
• W3083258145 cites W1982024247 @default.
• W3083258145 cites W1983172566 @default.
• W3083258145 cites W1994813225 @default.
• W3083258145 cites W1996620373 @default.
• W3083258145 cites W1997796132 @default.
• W3083258145 cites W1999748832 @default.
• W3083258145 cites W2002335472 @default.
• W3083258145 cites W2006004855 @default.
• W3083258145 cites W2008064384 @default.
• W3083258145 cites W2013501370 @default.
• W3083258145 cites W2016365146 @default.
• W3083258145 cites W2017140568 @default.
• W3083258145 cites W2019682430 @default.
• W3083258145 cites W2023365734 @default.
• W3083258145 cites W2032328584 @default.
• W3083258145 cites W2034351801 @default.
• W3083258145 cites W2035179613 @default.
• W3083258145 cites W2038352108 @default.
• W3083258145 cites W2048253776 @default.
• W3083258145 cites W2053347446 @default.
• W3083258145 cites W2058000100 @default.
• W3083258145 cites W2071795120 @default.
• W3083258145 cites W2074560044 @default.
• W3083258145 cites W2082162338 @default.
• W3083258145 cites W2082328088 @default.
• W3083258145 cites W2085313140 @default.
• W3083258145 cites W2090421973 @default.
• W3083258145 cites W2096308603 @default.
• W3083258145 cites W2097524602 @default.
• W3083258145 cites W2097703725 @default.
• W3083258145 cites W2104901763 @default.
• W3083258145 cites W2105946373 @default.
• W3083258145 cites W2131012576 @default.
• W3083258145 cites W2131195004 @default.
• W3083258145 cites W2135806287 @default.
• W3083258145 cites W2140603169 @default.
• W3083258145 cites W2141780560 @default.
• W3083258145 cites W2143088831 @default.
• W3083258145 cites W2148392331 @default.
• W3083258145 cites W2272403202 @default.
• W3083258145 cites W2286913354 @default.
• W3083258145 cites W2313307325 @default.
• W3083258145 cites W2347195557 @default.
• W3083258145 cites W2614486214 @default.
• W3083258145 cites W2734642652 @default.
• W3083258145 cites W2766938542 @default.
• W3083258145 cites W2771414227 @default.
• W3083258145 cites W2787141361 @default.
• W3083258145 cites W2790413481 @default.
• W3083258145 cites W2796176973 @default.
• W3083258145 cites W2797930460 @default.
• W3083258145 cites W2807140874 @default.
• W3083258145 cites W2883465051 @default.
• W3083258145 cites W2884188401 @default.
• W3083258145 cites W2896867935 @default.
• W3083258145 cites W2904105398 @default.
• W3083258145 cites W2941724686 @default.
• W3083258145 cites W2950165795 @default.
• W3083258145 cites W2951203730 @default.
• W3083258145 cites W2952908402 @default.
• W3083258145 cites W2968030808 @default.
• W3083258145 cites W2971400993 @default.
• W3083258145 cites W2982449184 @default.
• W3083258145 cites W2994373753 @default.
• W3083258145 cites W2996283875 @default.
• W3083258145 cites W2996746694 @default.
• W3083258145 cites W2998567095 @default.
• W3083258145 cites W3024890099 @default.
• W3083258145 cites W4244234373 @default.
• W3083258145 cites W4246986514 @default.
• W3083258145 cites W82186612 @default.
• W3083258145 doi "https://doi.org/10.2174/1389557520666200905125738" @default.
• W3083258145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32888265" @default.
• W3083258145 hasPublicationYear "2020" @default.
• W3083258145 type Work @default.
• W3083258145 sameAs 3083258145 @default.
• W3083258145 citedByCount "34" @default.
• W3083258145 countsByYear W30832581452021 @default.
• W3083258145 countsByYear W30832581452022 @default.
• W3083258145 countsByYear W30832581452023 @default.

• next