FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083284443> ?p ?o ?g. }

• W3083284443 endingPage "1421" @default.
• W3083284443 startingPage "1411" @default.
• W3083284443 abstract "Aims Current pharmacokinetic–pharmacodynamic models describing the haemodynamic changes often do not include necessary feedback mechanisms. These models provide adequate description of current data but may fail to adequately extrapolate to additional scenarios. This study aims to develop a minimal model to describe the short‐term changes of haemodynamics that can be used as the basis for model development by future researchers. Methods A minimal haemodynamic model was developed to describe the influence of drugs on blood pressure components. The model structure was defined based on known mechanisms and previously published models. The model was evaluated under 2 different simulation settings. The model parameters were calibrated to describe (without estimation) the haemodynamics of 2 antihypertensive drugs with data extracted from the literature. Structural identifiability analysis was done using various combinations of the observed variable. Results The proposed model structure includes mean arterial pressure, heart rate and stroke volume and is composed of 4 states described by differential equations. Model evaluation showed flexibility in describing the haemodynamics at different target perturbations. Overlay plots of model predictions and literature data showed a good description without data fitting. The structural identifiability analysis revealed all model parameters and initial conditions were identifiable only when heart rate, mean arterial pressure and cardiac output were measured together. Conclusions A minimal model of the haemodynamic system was developed and evaluated. The model accounted for short‐term haemodynamic feedback processes. We propose that this model can be used as the basis for future pharmacometric analyses of drugs acting on the haemodynamic system." @default.
• W3083284443 created "2020-09-11" @default.
• W3083284443 creator A5010082120 @default.
• W3083284443 creator A5037033929 @default.
• W3083284443 creator A5041172661 @default.
• W3083284443 date "2020-09-15" @default.
• W3083284443 modified "2023-09-26" @default.
• W3083284443 title "A minimal model to describe short‐term haemodynamic changes of the cardiovascular system" @default.
• W3083284443 cites W1484251943 @default.
• W3083284443 cites W1560270573 @default.
• W3083284443 cites W1951340309 @default.
• W3083284443 cites W1975508939 @default.
• W3083284443 cites W1986267161 @default.
• W3083284443 cites W1997979241 @default.
• W3083284443 cites W2012938800 @default.
• W3083284443 cites W2022743773 @default.
• W3083284443 cites W2029053821 @default.
• W3083284443 cites W2042443829 @default.
• W3083284443 cites W2043133079 @default.
• W3083284443 cites W2046697103 @default.
• W3083284443 cites W2055089767 @default.
• W3083284443 cites W2086577738 @default.
• W3083284443 cites W2134959284 @default.
• W3083284443 cites W2139321392 @default.
• W3083284443 cites W2192490292 @default.
• W3083284443 cites W2343238049 @default.
• W3083284443 cites W2541490590 @default.
• W3083284443 cites W2617822359 @default.
• W3083284443 cites W2746096210 @default.
• W3083284443 cites W2762759784 @default.
• W3083284443 cites W4239084611 @default.
• W3083284443 cites W4256353056 @default.
• W3083284443 doi "https://doi.org/10.1111/bcp.14541" @default.
• W3083284443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32886815" @default.
• W3083284443 hasPublicationYear "2020" @default.
• W3083284443 type Work @default.
• W3083284443 sameAs 3083284443 @default.
• W3083284443 citedByCount "4" @default.
• W3083284443 countsByYear W30832844432022 @default.
• W3083284443 countsByYear W30832844432023 @default.
• W3083284443 crossrefType "journal-article" @default.
• W3083284443 hasAuthorship W3083284443A5010082120 @default.
• W3083284443 hasAuthorship W3083284443A5037033929 @default.
• W3083284443 hasAuthorship W3083284443A5041172661 @default.
• W3083284443 hasBestOaLocation W30832844431 @default.
• W3083284443 hasConcept C105795698 @default.
• W3083284443 hasConcept C122770356 @default.
• W3083284443 hasConcept C126322002 @default.
• W3083284443 hasConcept C139940330 @default.
• W3083284443 hasConcept C164705383 @default.
• W3083284443 hasConcept C178853913 @default.
• W3083284443 hasConcept C2777953023 @default.
• W3083284443 hasConcept C33923547 @default.
• W3083284443 hasConcept C41008148 @default.
• W3083284443 hasConcept C71924100 @default.
• W3083284443 hasConcept C80461066 @default.
• W3083284443 hasConcept C84393581 @default.
• W3083284443 hasConceptScore W3083284443C105795698 @default.
• W3083284443 hasConceptScore W3083284443C122770356 @default.
• W3083284443 hasConceptScore W3083284443C126322002 @default.
• W3083284443 hasConceptScore W3083284443C139940330 @default.
• W3083284443 hasConceptScore W3083284443C164705383 @default.
• W3083284443 hasConceptScore W3083284443C178853913 @default.
• W3083284443 hasConceptScore W3083284443C2777953023 @default.
• W3083284443 hasConceptScore W3083284443C33923547 @default.
• W3083284443 hasConceptScore W3083284443C41008148 @default.
• W3083284443 hasConceptScore W3083284443C71924100 @default.
• W3083284443 hasConceptScore W3083284443C80461066 @default.
• W3083284443 hasConceptScore W3083284443C84393581 @default.
• W3083284443 hasIssue "3" @default.
• W3083284443 hasLocation W30832844431 @default.
• W3083284443 hasOpenAccess W3083284443 @default.
• W3083284443 hasPrimaryLocation W30832844431 @default.
• W3083284443 hasRelatedWork W2025123971 @default.
• W3083284443 hasRelatedWork W2074627437 @default.
• W3083284443 hasRelatedWork W2078774753 @default.
• W3083284443 hasRelatedWork W2087451805 @default.
• W3083284443 hasRelatedWork W2292437089 @default.
• W3083284443 hasRelatedWork W2401168026 @default.
• W3083284443 hasRelatedWork W2412222853 @default.
• W3083284443 hasRelatedWork W2438285002 @default.
• W3083284443 hasRelatedWork W2773393639 @default.
• W3083284443 hasRelatedWork W2794632142 @default.
• W3083284443 hasVolume "87" @default.
• W3083284443 isParatext "false" @default.
• W3083284443 isRetracted "false" @default.
• W3083284443 magId "3083284443" @default.
• W3083284443 workType "article" @default.