Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083303726> ?p ?o ?g. }
- W3083303726 abstract "Abstract Phase separation is an important mechanism that mediates the spatial distribution of proteins in different cellular compartments. While phase-separated proteins share certain sequence characteristics, including intrinsically disordered regions (IDRs) and prion-like domains, such characteristics are insufficient for making accurate predictions; thus, a proteome-wide understanding of phase separation is currently lacking. Here, we define phase-separated proteomes based on the systematic analysis of immunofluorescence images of 12 073 proteins in the Human Protein Atlas. The analysis of these proteins reveals that phase-separated candidate proteins exhibit higher IDR contents, higher mean net charge and lower hydropathy and prefer to bind to RNA. Kinases and transcription factors are also enriched among these candidate proteins. Strikingly, both phase-separated kinases and phase-separated transcription factors display significantly reduced substrate specificity. Our work provides the first global view of the phase-separated proteome and suggests that the spatial proximity resulting from phase separation reduces the requirement for motif specificity and expands the repertoire of substrates. The source code and data are available at https://github.com/cheneyyu/deepphase." @default.
- W3083303726 created "2020-09-11" @default.
- W3083303726 creator A5013689378 @default.
- W3083303726 creator A5020819058 @default.
- W3083303726 creator A5022050272 @default.
- W3083303726 creator A5028378330 @default.
- W3083303726 creator A5043128989 @default.
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- W3083303726 creator A5061396145 @default.
- W3083303726 creator A5080144646 @default.
- W3083303726 creator A5091910110 @default.
- W3083303726 date "2020-09-02" @default.
- W3083303726 modified "2023-10-16" @default.
- W3083303726 title "Proteome-scale analysis of phase-separated proteins in immunofluorescence images" @default.
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