FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083313144> ?p ?o ?g. }

• W3083313144 endingPage "75" @default.
• W3083313144 startingPage "68" @default.
• W3083313144 abstract "Abstract Background Phosphate is absorbed in the small intestine via passive flow and active transport.NaPi-IIb, a type II sodium-dependent phosphate transporter, is considered to mediate active phosphate transport in rodents. To study the regulation of intestinal phosphate transport in chronic kidney disease (CKD), we analyzed the expression levels of NaPi-IIb, pituitary-specific transcription factor 1 (PiT-1) and PiT-2 and the kinetics of intestinal phosphate transport using two CKD models. Methods CKD was induced in rats via adenine orThy1 antibody injection. Phosphate uptake by intestinal brush border membrane vesicles (BBMV) and the messenger RNA (mRNA) expression of NaPi-IIb, PiT-1 and PiT-2 were analyzed. The protein expression level of NaPi-IIb was measured by mass spectrometry (e.g. liquid chromatography tandem mass spectrometry). Results In normal rats, phosphate uptake into BBMV consisted of a single saturable component and its Michaelis constant (Km) was comparable to that of NaPi-IIb. The maximum velocity (Vmax) correlated with mRNA and protein levels of NaPi-IIb. In the CKD models, intestinal phosphate uptake consisted of two saturable components. The Vmax of the higher-affinity transport, which is thought to be responsible for NaPi-IIb, significantly decreased and the decrease correlated with reduced NaPi-IIb expression. The Km of the lower-affinity transport was comparable to that of PiT-1 and -2. PiT-1 mRNA expression was much higher than that of PiT-2, suggesting that PiT-1 was mostly responsible for phosphate transport. Conclusions This study suggests that the contribution of NaPi-IIb to intestinal phosphate absorption dramatically decreases in rats with CKD and that a low-affinity alternative to NaPi-IIb, in particular PiT-1, is upregulated in a compensatory manner in CKD." @default.
• W3083313144 created "2020-09-11" @default.
• W3083313144 creator A5001027249 @default.
• W3083313144 creator A5001620097 @default.
• W3083313144 creator A5023371530 @default.
• W3083313144 creator A5030679685 @default.
• W3083313144 creator A5058975508 @default.
• W3083313144 creator A5062187402 @default.
• W3083313144 creator A5065225304 @default.
• W3083313144 creator A5069476050 @default.
• W3083313144 creator A5074116678 @default.
• W3083313144 creator A5078224213 @default.
• W3083313144 date "2020-09-03" @default.
• W3083313144 modified "2023-10-18" @default.
• W3083313144 title "Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease" @default.
• W3083313144 cites W1963541108 @default.
• W3083313144 cites W1974113322 @default.
• W3083313144 cites W1988330339 @default.
• W3083313144 cites W1989624450 @default.
• W3083313144 cites W1989716397 @default.
• W3083313144 cites W2000967798 @default.
• W3083313144 cites W2009466544 @default.
• W3083313144 cites W2037687164 @default.
• W3083313144 cites W2045411633 @default.
• W3083313144 cites W2048950527 @default.
• W3083313144 cites W2052761282 @default.
• W3083313144 cites W2062563034 @default.
• W3083313144 cites W2071120958 @default.
• W3083313144 cites W2072981607 @default.
• W3083313144 cites W2076964687 @default.
• W3083313144 cites W2090458713 @default.
• W3083313144 cites W2107207648 @default.
• W3083313144 cites W2111018220 @default.
• W3083313144 cites W2117639138 @default.
• W3083313144 cites W2122037712 @default.
• W3083313144 cites W2131395923 @default.
• W3083313144 cites W2137451580 @default.
• W3083313144 cites W2143657892 @default.
• W3083313144 cites W2161689969 @default.
• W3083313144 cites W2504996048 @default.
• W3083313144 cites W2743203236 @default.
• W3083313144 cites W2767856502 @default.
• W3083313144 cites W2789335667 @default.
• W3083313144 cites W2897009503 @default.
• W3083313144 cites W2904787150 @default.
• W3083313144 cites W3007472566 @default.
• W3083313144 cites W3020178333 @default.
• W3083313144 doi "https://doi.org/10.1093/ndt/gfaa156" @default.
• W3083313144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7771979" @default.
• W3083313144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32879980" @default.
• W3083313144 hasPublicationYear "2020" @default.
• W3083313144 type Work @default.
• W3083313144 sameAs 3083313144 @default.
• W3083313144 citedByCount "13" @default.
• W3083313144 countsByYear W30833131442021 @default.
• W3083313144 countsByYear W30833131442022 @default.
• W3083313144 countsByYear W30833131442023 @default.
• W3083313144 crossrefType "journal-article" @default.
• W3083313144 hasAuthorship W3083313144A5001027249 @default.
• W3083313144 hasAuthorship W3083313144A5001620097 @default.
• W3083313144 hasAuthorship W3083313144A5023371530 @default.
• W3083313144 hasAuthorship W3083313144A5030679685 @default.
• W3083313144 hasAuthorship W3083313144A5058975508 @default.
• W3083313144 hasAuthorship W3083313144A5062187402 @default.
• W3083313144 hasAuthorship W3083313144A5065225304 @default.
• W3083313144 hasAuthorship W3083313144A5069476050 @default.
• W3083313144 hasAuthorship W3083313144A5074116678 @default.
• W3083313144 hasAuthorship W3083313144A5078224213 @default.
• W3083313144 hasBestOaLocation W30833131441 @default.
• W3083313144 hasConcept C104317684 @default.
• W3083313144 hasConcept C105580179 @default.
• W3083313144 hasConcept C120405084 @default.
• W3083313144 hasConcept C126322002 @default.
• W3083313144 hasConcept C130316041 @default.
• W3083313144 hasConcept C134018914 @default.
• W3083313144 hasConcept C149011108 @default.
• W3083313144 hasConcept C178790620 @default.
• W3083313144 hasConcept C185592680 @default.
• W3083313144 hasConcept C2777132085 @default.
• W3083313144 hasConcept C2777882243 @default.
• W3083313144 hasConcept C2780091579 @default.
• W3083313144 hasConcept C41625074 @default.
• W3083313144 hasConcept C537181965 @default.
• W3083313144 hasConcept C5426402 @default.
• W3083313144 hasConcept C55493867 @default.
• W3083313144 hasConcept C71924100 @default.
• W3083313144 hasConcept C86803240 @default.
• W3083313144 hasConceptScore W3083313144C104317684 @default.
• W3083313144 hasConceptScore W3083313144C105580179 @default.
• W3083313144 hasConceptScore W3083313144C120405084 @default.
• W3083313144 hasConceptScore W3083313144C126322002 @default.
• W3083313144 hasConceptScore W3083313144C130316041 @default.
• W3083313144 hasConceptScore W3083313144C134018914 @default.
• W3083313144 hasConceptScore W3083313144C149011108 @default.
• W3083313144 hasConceptScore W3083313144C178790620 @default.
• W3083313144 hasConceptScore W3083313144C185592680 @default.
• W3083313144 hasConceptScore W3083313144C2777132085 @default.
• W3083313144 hasConceptScore W3083313144C2777882243 @default.

• next