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- W3083339749 abstract "Significance Intracellular pathogens utilize specialized mechanisms for replicating within host cells while minimizing cytotoxicity. Misregulation of bacterial virulence factors that are responsible for infection can cause host cell death and the consequent loss of virulence. The results presented here reveal that the translation of a cytolysin that is responsible for host infection is reduced during bacterial growth, due to the formation of an mRNA secondary structure that results in translational inhibition. The coding domain that occludes the ribosome binding site regulates the synthesis and activity of the cytolysin inside the host cytosol, highlighting multiple levels of LLO control from this domain. These findings provide insight into how expression of a virulence factor can be translationally regulated within alternate host cellular compartments." @default.
- W3083339749 created "2020-09-11" @default.
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- W3083339749 date "2020-09-02" @default.
- W3083339749 modified "2023-09-24" @default.
- W3083339749 title "Secondary structure of the mRNA encoding listeriolysin O is essential to establish the replicative niche of <i>L. monocytogenes</i>" @default.
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- W3083339749 doi "https://doi.org/10.1073/pnas.2004129117" @default.
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