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• W3083350277 endingPage "1100" @default.
• W3083350277 startingPage "1079" @default.
• W3083350277 abstract "Abstract In spite of substantial progress made toward understanding cancer pathogenesis, this disease remains one of the leading causes of mortality. Thus, there is an urgent need to develop novel, more effective anticancer therapeutics. Thiadiazole ring is a versatile scaffold widely studied in medicinal chemistry. Mesoionic character of this ring allows thiadiazole-containing compounds to cross cellular membrane and interact strongly with biological targets. Consequently, these compounds exert a broad spectrum of biological activities. This review presents the current state of knowledge on thiadiazole derivatives that demonstrate in vitro and/or in vivo efficacy across the cancer models with an emphasis on targets of action. The influence of the substituent on the compounds’ activity is depicted. Furthermore, the results from clinical trials assessing thiadiazole-containing drugs in cancer patients are summarized." @default.
• W3083350277 created "2020-09-11" @default.
• W3083350277 creator A5019431038 @default.
• W3083350277 date "2020-09-03" @default.
• W3083350277 modified "2023-10-16" @default.
• W3083350277 title "Thiadiazole derivatives as anticancer agents" @default.
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