Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083377677> ?p ?o ?g. }
- W3083377677 abstract "Abstract To improve the prognosis of glioblastoma, innovative radiotherapy regimens are required to augment the effect of tolerable radiation doses while sparing surrounding tissues. In this context, nanoscintillators are emerging radiotherapeutics that down‐convert X‐rays into photons with energies ranging from UV to near‐infrared. During radiotherapy, these scintillating properties amplify radiation‐induced damage by UV‐C emission or photodynamic effects. Additionally, nanoscintillators that contain high‐Z elements are likely to induce another, currently unexplored effect: radiation dose‐enhancement. This phenomenon stems from a higher photoelectric absorption of orthovoltage X‐rays by high‐Z elements compared to tissues, resulting in increased production of tissue‐damaging photo‐ and Auger electrons. In this study, Geant4 simulations reveal that rare‐earth composite LaF 3 :Ce nanoscintillators effectively generate photo‐ and Auger‐electrons upon orthovoltage X‐rays. 3D spatially resolved X‐ray fluorescence microtomography shows that LaF 3 :Ce highly concentrates in microtumors and enhances radiotherapy in an X‐ray energy‐dependent manner. In an aggressive syngeneic model of orthotopic glioblastoma, intracerebral injection of LaF 3 :Ce is well tolerated and achieves complete tumor remission in 15% of the subjects receiving monochromatic synchrotron radiotherapy. This study provides unequivocal evidence for radiation dose‐enhancement by nanoscintillators, eliciting a prominent radiotherapeutic effect. Altogether, nanoscintillators have invaluable properties for enhancing the focal damage of radiotherapy in glioblastoma and other radioresistant cancers." @default.
- W3083377677 created "2020-09-11" @default.
- W3083377677 creator A5002417486 @default.
- W3083377677 creator A5009505184 @default.
- W3083377677 creator A5016558151 @default.
- W3083377677 creator A5026533053 @default.
- W3083377677 creator A5027147021 @default.
- W3083377677 creator A5041930080 @default.
- W3083377677 creator A5050373271 @default.
- W3083377677 creator A5051623571 @default.
- W3083377677 creator A5053063756 @default.
- W3083377677 creator A5054990003 @default.
- W3083377677 creator A5058229780 @default.
- W3083377677 creator A5071662921 @default.
- W3083377677 creator A5073769299 @default.
- W3083377677 creator A5088331545 @default.
- W3083377677 creator A5090905861 @default.
- W3083377677 date "2020-09-07" @default.
- W3083377677 modified "2023-10-18" @default.
- W3083377677 title "Radiation Dose‐Enhancement Is a Potent Radiotherapeutic Effect of Rare‐Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma" @default.
- W3083377677 cites W1514871629 @default.
- W3083377677 cites W1603334805 @default.
- W3083377677 cites W1659720364 @default.
- W3083377677 cites W1681867927 @default.
- W3083377677 cites W1828660051 @default.
- W3083377677 cites W1878980338 @default.
- W3083377677 cites W1891900466 @default.
- W3083377677 cites W191454705 @default.
- W3083377677 cites W1968256046 @default.
- W3083377677 cites W1971659905 @default.
- W3083377677 cites W1985006984 @default.
- W3083377677 cites W1995322749 @default.
- W3083377677 cites W200854152 @default.
- W3083377677 cites W2015138239 @default.
- W3083377677 cites W2018895767 @default.
- W3083377677 cites W2029480253 @default.
- W3083377677 cites W2031515625 @default.
- W3083377677 cites W2033474014 @default.
- W3083377677 cites W2034421254 @default.
- W3083377677 cites W2038613867 @default.
- W3083377677 cites W2042744299 @default.
- W3083377677 cites W2046561846 @default.
- W3083377677 cites W2050988697 @default.
- W3083377677 cites W2052745473 @default.
- W3083377677 cites W2053982860 @default.
- W3083377677 cites W2055627887 @default.
- W3083377677 cites W2060420887 @default.
- W3083377677 cites W2066659850 @default.
- W3083377677 cites W2076845623 @default.
- W3083377677 cites W2078860264 @default.
- W3083377677 cites W2090323597 @default.
- W3083377677 cites W2094163596 @default.
- W3083377677 cites W2094777679 @default.
- W3083377677 cites W2094927447 @default.
- W3083377677 cites W2096287682 @default.
- W3083377677 cites W2097157816 @default.
- W3083377677 cites W2102073707 @default.
- W3083377677 cites W2102415535 @default.
- W3083377677 cites W2110741904 @default.
- W3083377677 cites W2112028524 @default.
- W3083377677 cites W2113931031 @default.
- W3083377677 cites W2115080515 @default.
- W3083377677 cites W2117141495 @default.
- W3083377677 cites W2128158076 @default.
- W3083377677 cites W2129248052 @default.
- W3083377677 cites W2139534622 @default.
- W3083377677 cites W2145238798 @default.
- W3083377677 cites W2168672718 @default.
- W3083377677 cites W2171351334 @default.
- W3083377677 cites W2172096869 @default.
- W3083377677 cites W2324132447 @default.
- W3083377677 cites W2332310273 @default.
- W3083377677 cites W2332423385 @default.
- W3083377677 cites W2404309494 @default.
- W3083377677 cites W2433010802 @default.
- W3083377677 cites W2520891840 @default.
- W3083377677 cites W2528789251 @default.
- W3083377677 cites W2533400036 @default.
- W3083377677 cites W2551798103 @default.
- W3083377677 cites W2577305611 @default.
- W3083377677 cites W2597570800 @default.
- W3083377677 cites W2742204633 @default.
- W3083377677 cites W2744106462 @default.
- W3083377677 cites W2753186032 @default.
- W3083377677 cites W2769598836 @default.
- W3083377677 cites W2783126485 @default.
- W3083377677 cites W2792345771 @default.
- W3083377677 cites W2799892346 @default.
- W3083377677 cites W2802535891 @default.
- W3083377677 cites W2804345283 @default.
- W3083377677 cites W2805287204 @default.
- W3083377677 cites W2810105253 @default.
- W3083377677 cites W2811182413 @default.
- W3083377677 cites W2884280298 @default.
- W3083377677 cites W2902615480 @default.
- W3083377677 cites W2907458715 @default.
- W3083377677 cites W2922390616 @default.
- W3083377677 cites W2930348834 @default.
- W3083377677 cites W2946016507 @default.
- W3083377677 cites W2967345928 @default.