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- W3083382503 abstract "Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death. Emerging evidence suggests that hypoxia-inducible factor (HIF) signaling plays a fundamental and pivotal role in the pathogenesis of PH. This Review summarizes the regulation of HIF isoforms and their impact in various PH subtypes, as well as the elaborate conditional and cell-specific knockout mouse studies that brought the role of this pathway to light. We also discuss the current preclinical status of pan- and isoform-selective HIF inhibitors, and propose new research areas that may facilitate HIF isoform-specific inhibition as a novel therapeutic strategy for PH and right heart failure." @default.
- W3083382503 created "2020-09-11" @default.
- W3083382503 creator A5016511599 @default.
- W3083382503 creator A5057524424 @default.
- W3083382503 creator A5066375665 @default.
- W3083382503 creator A5072984121 @default.
- W3083382503 date "2020-09-28" @default.
- W3083382503 modified "2023-10-16" @default.
- W3083382503 title "Hypoxia-inducible factor signaling in pulmonary hypertension" @default.
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