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- W3083441543 abstract "Alzheimer’s disease (AD) is the common cause ofdementia which shows the neuro-pathologies like an accumulation of amyloid-β (Aβ)and degeneration of cholinergic neuron. Olfactory bulbectomized (OBX) mice showsome of AD features, so they have been used to research as AD model.Mesenchymal stem cells (MSCs) can differentiate into many kinds of cells,including neuronal cells. In this study, we intranasally administrated theconditioned medium derived from cultured umbilical cord (UC) MSCs. Theintranasal administration of the MSCs medium restored the cognitive impairmentobserved in OBX mice. In addition, the decreased number of cholineacetyltransferase-positive cells in the medial septum was restored by theconditioned medium administration. In conclusion, MSCs-derived conditionedmedium may have protective effects of cholinergic neurons in the medial septum,thereby rescuing the cognitive impairment of OBX." @default.
- W3083441543 created "2020-09-11" @default.
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- W3083441543 date "2020-01-01" @default.
- W3083441543 modified "2023-09-29" @default.
- W3083441543 title "Intranasal Administration of Conditioned Medium from Cultured Mesenchymal Stem Cells Improves Cognitive Impairment in Olfactory Bulbectomized Mice" @default.
- W3083441543 doi "https://doi.org/10.4236/aad.2020.93004" @default.
- W3083441543 hasPublicationYear "2020" @default.
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