FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083497169> ?p ?o ?g. }

• W3083497169 abstract "Background Coronary artery disease (CAD) has been recognized as a serious and potentially life‐threatening complication of Hepatitis C Virus (HCV) infection. High on‐treatment platelet reactivity has been associated with high risk of ischemic events in patients with CAD, but data regarding the association with HCV infection are still lacking. This post hoc analysis aims to assess high on‐treatment platelet reactivity, severity of CAD, and long‐term outcomes of patients with acute coronary syndrome (ACS) who were infected with HCV. Methods and Results Patients with ACS who were infected with HCV (n=47) were matched to patients with ACS and without HCV (n=137) for age, sex, diabetes mellitus, hypertension, and renal function. HCV‐infected patients with ACS had higher levels of platelet reactivity (ADP 10 –light transmittance aggregometry, 56±18% versus 44±22% [ P =0.002]; arachidonic acid–light transmittance aggregometry, 25±21% versus 16±15% [ P =0.011]) and higher rates of high on‐treatment platelet reactivity on clopidogrel and aspirin compared with patients without HCV. Moreover, HCV‐infected patients with ACS had higher rates of multivessel disease (53% versus 30%; P =0.004) and 3‐vessel disease (32% versus 7%; P <0.001) compared with patients without HCV. At long‐term follow‐up, estimated rates of major adverse cardiovascular events (cardiac death, nonfatal myocardial infarction, and ischemia‐driven revascularization) were 57% versus 34% ( P =0.005) in HCV‐ and non–HCV‐infected patients with ACS, respectively. In addition, thrombolysis In Myocardial Infarction (TIMI) major bleeding rates were higher in HCV‐infected patients (11% versus 3%; P =0.043) compared with noninfected patients. Multivariable analysis demonstrated that HCV infection was an independent predictor of high on‐treatment platelet reactivity, severity of CAD, and long‐term outcome. Conclusions In this hypothesis‐generating study, patients with ACS and HCV infection showed increased on‐treatment platelet reactivity, more severe CAD, and worse prognosis compared with patients without HCV." @default.
• W3083497169 created "2020-09-11" @default.
• W3083497169 creator A5004032203 @default.
• W3083497169 creator A5004617206 @default.
• W3083497169 creator A5006597199 @default.
• W3083497169 creator A5008352332 @default.
• W3083497169 creator A5011842156 @default.
• W3083497169 creator A5015252581 @default.
• W3083497169 creator A5053916137 @default.
• W3083497169 creator A5070057174 @default.
• W3083497169 creator A5074401377 @default.
• W3083497169 creator A5076179755 @default.
• W3083497169 creator A5077983160 @default.
• W3083497169 creator A5079517355 @default.
• W3083497169 creator A5084827245 @default.
• W3083497169 date "2020-09-15" @default.
• W3083497169 modified "2023-09-27" @default.
• W3083497169 title "Platelet Reactivity in Hepatitis C Virus–Infected Patients on Dual Antiplatelet Therapy for Acute Coronary Syndrome" @default.
• W3083497169 cites W1954289452 @default.
• W3083497169 cites W1977300462 @default.
• W3083497169 cites W2005790383 @default.
• W3083497169 cites W2011181737 @default.
• W3083497169 cites W2019546826 @default.
• W3083497169 cites W2029179690 @default.
• W3083497169 cites W2054757259 @default.
• W3083497169 cites W2060063218 @default.
• W3083497169 cites W2063119789 @default.
• W3083497169 cites W2070024133 @default.
• W3083497169 cites W2076472209 @default.
• W3083497169 cites W2114848625 @default.
• W3083497169 cites W2114965058 @default.
• W3083497169 cites W2170880806 @default.
• W3083497169 cites W2232103699 @default.
• W3083497169 cites W2239019861 @default.
• W3083497169 cites W2600797837 @default.
• W3083497169 cites W2742683725 @default.
• W3083497169 cites W2767217085 @default.
• W3083497169 cites W2793862312 @default.
• W3083497169 cites W2965243229 @default.
• W3083497169 doi "https://doi.org/10.1161/jaha.120.016441" @default.
• W3083497169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7726996" @default.
• W3083497169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32885738" @default.
• W3083497169 hasPublicationYear "2020" @default.
• W3083497169 type Work @default.
• W3083497169 sameAs 3083497169 @default.
• W3083497169 citedByCount "6" @default.
• W3083497169 countsByYear W30834971692021 @default.
• W3083497169 countsByYear W30834971692022 @default.
• W3083497169 countsByYear W30834971692023 @default.
• W3083497169 crossrefType "journal-article" @default.
• W3083497169 hasAuthorship W3083497169A5004032203 @default.
• W3083497169 hasAuthorship W3083497169A5004617206 @default.
• W3083497169 hasAuthorship W3083497169A5006597199 @default.
• W3083497169 hasAuthorship W3083497169A5008352332 @default.
• W3083497169 hasAuthorship W3083497169A5011842156 @default.
• W3083497169 hasAuthorship W3083497169A5015252581 @default.
• W3083497169 hasAuthorship W3083497169A5053916137 @default.
• W3083497169 hasAuthorship W3083497169A5070057174 @default.
• W3083497169 hasAuthorship W3083497169A5074401377 @default.
• W3083497169 hasAuthorship W3083497169A5076179755 @default.
• W3083497169 hasAuthorship W3083497169A5077983160 @default.
• W3083497169 hasAuthorship W3083497169A5079517355 @default.
• W3083497169 hasAuthorship W3083497169A5084827245 @default.
• W3083497169 hasBestOaLocation W30834971691 @default.
• W3083497169 hasConcept C126322002 @default.
• W3083497169 hasConcept C134018914 @default.
• W3083497169 hasConcept C164705383 @default.
• W3083497169 hasConcept C203014093 @default.
• W3083497169 hasConcept C2522874641 @default.
• W3083497169 hasConcept C2776408679 @default.
• W3083497169 hasConcept C2776455275 @default.
• W3083497169 hasConcept C2777628954 @default.
• W3083497169 hasConcept C2777698277 @default.
• W3083497169 hasConcept C2777849778 @default.
• W3083497169 hasConcept C2778213512 @default.
• W3083497169 hasConcept C2780400711 @default.
• W3083497169 hasConcept C500558357 @default.
• W3083497169 hasConcept C555293320 @default.
• W3083497169 hasConcept C71924100 @default.
• W3083497169 hasConceptScore W3083497169C126322002 @default.
• W3083497169 hasConceptScore W3083497169C134018914 @default.
• W3083497169 hasConceptScore W3083497169C164705383 @default.
• W3083497169 hasConceptScore W3083497169C203014093 @default.
• W3083497169 hasConceptScore W3083497169C2522874641 @default.
• W3083497169 hasConceptScore W3083497169C2776408679 @default.
• W3083497169 hasConceptScore W3083497169C2776455275 @default.
• W3083497169 hasConceptScore W3083497169C2777628954 @default.
• W3083497169 hasConceptScore W3083497169C2777698277 @default.
• W3083497169 hasConceptScore W3083497169C2777849778 @default.
• W3083497169 hasConceptScore W3083497169C2778213512 @default.
• W3083497169 hasConceptScore W3083497169C2780400711 @default.
• W3083497169 hasConceptScore W3083497169C500558357 @default.
• W3083497169 hasConceptScore W3083497169C555293320 @default.
• W3083497169 hasConceptScore W3083497169C71924100 @default.
• W3083497169 hasIssue "18" @default.
• W3083497169 hasLocation W30834971691 @default.
• W3083497169 hasLocation W30834971692 @default.
• W3083497169 hasLocation W30834971693 @default.
• W3083497169 hasOpenAccess W3083497169 @default.
• W3083497169 hasPrimaryLocation W30834971691 @default.

• next