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- W3083572703 abstract "Abstract The perfusion-based in vitro three-dimensional (3D) tumor models built on the microfluidic technology are leading the current research in tumor modeling for testing anticancer drugs/agents. The conventional two-dimensional in vitro and animal models used in preclinical drug development have many drawbacks. Tumor models based on the microfluidic principles and technology promise to overcome many of those drawbacks. The inclusion of physiological tumor parameters on a microscale chip is beneficial in obtaining precise tumor pathology and meaningful drug responses, which can aid in predicting human clinical drug outcomes. In this chapter, we mainly focus on the microphysiological models, which have a flow component in the device design, and their maturation toward highly complex multiorgan systems. The microfluidic tumor models incorporating pharmacokinetics and pharmacodynamics (PK/PD) of anticancer drugs are explained. Finally, we discuss the challenges involved in the determination of drug absorption, distribution, metabolism, excretion, and toxicity, along with the recently developed 3D microfluidic tumor models that can help acquire these data as per the mathematical PK/PD models." @default.
- W3083572703 created "2020-09-11" @default.
- W3083572703 creator A5069647011 @default.
- W3083572703 creator A5091205492 @default.
- W3083572703 date "2020-01-01" @default.
- W3083572703 modified "2023-10-14" @default.
- W3083572703 title "Perfusion-based 3D tumor-on-chip devices for anticancer drug testing" @default.
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- W3083572703 cites W1901255537 @default.
- W3083572703 cites W1969160840 @default.
- W3083572703 cites W1975042334 @default.
- W3083572703 cites W1978496495 @default.
- W3083572703 cites W1979665070 @default.
- W3083572703 cites W1981909768 @default.
- W3083572703 cites W1997362383 @default.
- W3083572703 cites W1998048991 @default.
- W3083572703 cites W2005334224 @default.
- W3083572703 cites W2013520568 @default.
- W3083572703 cites W2017656225 @default.
- W3083572703 cites W2022941161 @default.
- W3083572703 cites W2043668209 @default.
- W3083572703 cites W2061454786 @default.
- W3083572703 cites W2062809449 @default.
- W3083572703 cites W2066724170 @default.
- W3083572703 cites W2081560083 @default.
- W3083572703 cites W2089409749 @default.
- W3083572703 cites W2090221057 @default.
- W3083572703 cites W2093082279 @default.
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- W3083572703 cites W2102197759 @default.
- W3083572703 cites W2103438502 @default.
- W3083572703 cites W2112791462 @default.
- W3083572703 cites W2116167491 @default.
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- W3083572703 doi "https://doi.org/10.1016/b978-0-12-818128-7.00016-2" @default.
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