Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083594297> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3083594297 endingPage "4935" @default.
- W3083594297 startingPage "4929" @default.
- W3083594297 abstract "Background: Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are frequently found in various cancer types. IDH1 mutants produce 2-hydroxyglutarate (2-HG), an oncometabolite, from alpha-ketoglutarate (α-KG). This 2-HG plays a key role in tumorigenesis via inhibition of α-KG dependent enzymes. For this reason, IDH1 mutant could be an ideal target for the treatment of cancer. Materials and Methods: To find a new IDH1 inhibitor, 8,364 compounds were obtained from Korea Chemical Bank. Using high-throughput screening (HTS) of a chemical library, we unveiled a compound that could inhibit the IDH1 mutant. Results: According to the enzyme assay, our compound (KRC-09) effectively inhibited the activity of IDH1 R132H mutant. In addition, KRC-09 decreased the concentration of intracellular 2-HG in the U-87 MG cell line harboring IDH1 R132H. Conclusion: In this article, we present a novel chemical scaffold that suppresses the activity of an IDH1 mutant." @default.
- W3083594297 created "2020-09-11" @default.
- W3083594297 creator A5004485236 @default.
- W3083594297 creator A5013570464 @default.
- W3083594297 creator A5027714559 @default.
- W3083594297 creator A5027814766 @default.
- W3083594297 creator A5039900427 @default.
- W3083594297 creator A5057471843 @default.
- W3083594297 creator A5064201606 @default.
- W3083594297 creator A5077243453 @default.
- W3083594297 date "2020-09-01" @default.
- W3083594297 modified "2023-09-26" @default.
- W3083594297 title "Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1)" @default.
- W3083594297 doi "https://doi.org/10.21873/anticanres.14496" @default.
- W3083594297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32878781" @default.
- W3083594297 hasPublicationYear "2020" @default.
- W3083594297 type Work @default.
- W3083594297 sameAs 3083594297 @default.
- W3083594297 citedByCount "3" @default.
- W3083594297 countsByYear W30835942972022 @default.
- W3083594297 countsByYear W30835942972023 @default.
- W3083594297 crossrefType "journal-article" @default.
- W3083594297 hasAuthorship W3083594297A5004485236 @default.
- W3083594297 hasAuthorship W3083594297A5013570464 @default.
- W3083594297 hasAuthorship W3083594297A5027714559 @default.
- W3083594297 hasAuthorship W3083594297A5027814766 @default.
- W3083594297 hasAuthorship W3083594297A5039900427 @default.
- W3083594297 hasAuthorship W3083594297A5057471843 @default.
- W3083594297 hasAuthorship W3083594297A5064201606 @default.
- W3083594297 hasAuthorship W3083594297A5077243453 @default.
- W3083594297 hasBestOaLocation W30835942971 @default.
- W3083594297 hasConcept C104317684 @default.
- W3083594297 hasConcept C127848430 @default.
- W3083594297 hasConcept C143065580 @default.
- W3083594297 hasConcept C161624437 @default.
- W3083594297 hasConcept C181199279 @default.
- W3083594297 hasConcept C185592680 @default.
- W3083594297 hasConcept C2777150147 @default.
- W3083594297 hasConcept C2779057010 @default.
- W3083594297 hasConcept C502942594 @default.
- W3083594297 hasConcept C55493867 @default.
- W3083594297 hasConcept C555283112 @default.
- W3083594297 hasConcept C86803240 @default.
- W3083594297 hasConceptScore W3083594297C104317684 @default.
- W3083594297 hasConceptScore W3083594297C127848430 @default.
- W3083594297 hasConceptScore W3083594297C143065580 @default.
- W3083594297 hasConceptScore W3083594297C161624437 @default.
- W3083594297 hasConceptScore W3083594297C181199279 @default.
- W3083594297 hasConceptScore W3083594297C185592680 @default.
- W3083594297 hasConceptScore W3083594297C2777150147 @default.
- W3083594297 hasConceptScore W3083594297C2779057010 @default.
- W3083594297 hasConceptScore W3083594297C502942594 @default.
- W3083594297 hasConceptScore W3083594297C55493867 @default.
- W3083594297 hasConceptScore W3083594297C555283112 @default.
- W3083594297 hasConceptScore W3083594297C86803240 @default.
- W3083594297 hasIssue "9" @default.
- W3083594297 hasLocation W30835942971 @default.
- W3083594297 hasLocation W30835942972 @default.
- W3083594297 hasOpenAccess W3083594297 @default.
- W3083594297 hasPrimaryLocation W30835942971 @default.
- W3083594297 hasRelatedWork W1834004242 @default.
- W3083594297 hasRelatedWork W2029813482 @default.
- W3083594297 hasRelatedWork W2043801539 @default.
- W3083594297 hasRelatedWork W2069874131 @default.
- W3083594297 hasRelatedWork W2087383467 @default.
- W3083594297 hasRelatedWork W2157219413 @default.
- W3083594297 hasRelatedWork W2740327985 @default.
- W3083594297 hasRelatedWork W2767753965 @default.
- W3083594297 hasRelatedWork W2887948931 @default.
- W3083594297 hasRelatedWork W3083594297 @default.
- W3083594297 hasVolume "40" @default.
- W3083594297 isParatext "false" @default.
- W3083594297 isRetracted "false" @default.
- W3083594297 magId "3083594297" @default.
- W3083594297 workType "article" @default.