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- W3083663573 endingPage "6541" @default.
- W3083663573 startingPage "6541" @default.
- W3083663573 abstract "The root bark of Morus has long been appreciated as an antiphlogistic, diuretic and expectorant drug in Chinese herbal medicine, albeit with barely known targets and mechanisms of action. In the 1970s, the development of analytic chemistry allowed for the discovery of morusin as one of 7 different isoprene flavonoid derivatives in the root bark of Morus. However, the remarkable antioxidant capacity of morusin with the unexpected potential for health benefits over the other flavonoid derivatives has recently sparked scientific interest in the biochemical identification of target proteins and signaling pathways and further clinical relevance. In this review, we discuss recent advances in the understanding of the functional roles of morusin in multiple biological processes such as inflammation, apoptosis, metabolism and autophagy. We also highlight recent in vivo and in vitro evidence on the clinical potential of morusin treatment for multiple human pathologies including inflammatory diseases, neurological disorders, diabetes, cancer and the underlying mechanisms." @default.
- W3083663573 created "2020-09-11" @default.
- W3083663573 creator A5008602625 @default.
- W3083663573 creator A5018527317 @default.
- W3083663573 creator A5070241434 @default.
- W3083663573 creator A5074305621 @default.
- W3083663573 date "2020-09-07" @default.
- W3083663573 modified "2023-10-16" @default.
- W3083663573 title "The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus" @default.
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- W3083663573 doi "https://doi.org/10.3390/ijms21186541" @default.
- W3083663573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7554996" @default.