FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083695748> ?p ?o ?g. }

• W3083695748 abstract "The causal role of abdominal overweight/obesity, insulin resistance and type 2 diabetes (T2D) on the risk of fatty liver disease (FLD) has robustly been proven. A consensus of experts has recently proposed the novel definition of 'metabolic dysfunction-associated fatty liver disease, MAFLD' instead of 'nonalcoholic fatty liver disease, NAFLD', emphasizing the central role of dysmetabolism in the disease pathogenesis. Conversely, a direct and independent contribution of FLD per se on risk of developing T2D is still a controversial topic. When dealing with FLD as a potential risk factor for T2D, it is straightforward to think of hepatic insulin resistance as the most relevant underlying mechanism. Emerging evidence supports genetic determinants of FLD (eg PNPLA3, TM6SF2, MBOAT7, GCKR, HSD17B13) as determinants of insulin resistance and T2D. However, recent studies highlighted that the key molecular mechanism of dysmetabolism is not fat accumulation per se but the degree of hepatic fibrosis (excess liver fat content-lipotoxicity), leading to reduced insulin clearance, insulin resistance and T2D. A consequence of these findings is that drugs that will ameliorate liver fat accumulation and fibrosis in principle may also exert a beneficial effect on insulin resistance and risk of T2D in individuals with FLD. Finally, initial findings show that these genetic factors might be directly implicated in modulating pancreatic beta-cell function, although future studies are needed to fully understand this relationship." @default.
• W3083695748 created "2020-09-11" @default.
• W3083695748 creator A5020610956 @default.
• W3083695748 creator A5050497878 @default.
• W3083695748 creator A5071075382 @default.
• W3083695748 creator A5085747588 @default.
• W3083695748 date "2020-09-04" @default.
• W3083695748 modified "2023-10-10" @default.
• W3083695748 title "Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum" @default.
• W3083695748 cites W1261333696 @default.
• W3083695748 cites W1480578020 @default.
• W3083695748 cites W1778491839 @default.
• W3083695748 cites W1957097754 @default.
• W3083695748 cites W1964328466 @default.
• W3083695748 cites W1964858015 @default.
• W3083695748 cites W1965712234 @default.
• W3083695748 cites W1966549856 @default.
• W3083695748 cites W1973181261 @default.
• W3083695748 cites W1979443397 @default.
• W3083695748 cites W1981452461 @default.
• W3083695748 cites W1984916469 @default.
• W3083695748 cites W1990010616 @default.
• W3083695748 cites W1992182388 @default.
• W3083695748 cites W1993536642 @default.
• W3083695748 cites W2000537121 @default.
• W3083695748 cites W2009138882 @default.
• W3083695748 cites W2010120356 @default.
• W3083695748 cites W2017511982 @default.
• W3083695748 cites W2018207417 @default.
• W3083695748 cites W2030379010 @default.
• W3083695748 cites W2034160355 @default.
• W3083695748 cites W2034280561 @default.
• W3083695748 cites W2037621705 @default.
• W3083695748 cites W2048755332 @default.
• W3083695748 cites W2056315356 @default.
• W3083695748 cites W2062812115 @default.
• W3083695748 cites W2071991978 @default.
• W3083695748 cites W2092357969 @default.
• W3083695748 cites W2096629131 @default.
• W3083695748 cites W2097249828 @default.
• W3083695748 cites W2106768039 @default.
• W3083695748 cites W2109371472 @default.
• W3083695748 cites W2110027329 @default.
• W3083695748 cites W2113052184 @default.
• W3083695748 cites W2113743121 @default.
• W3083695748 cites W2119913660 @default.
• W3083695748 cites W2121351699 @default.
• W3083695748 cites W2124311658 @default.
• W3083695748 cites W2127155067 @default.
• W3083695748 cites W2141137906 @default.
• W3083695748 cites W2142658017 @default.
• W3083695748 cites W2150373708 @default.
• W3083695748 cites W2153554912 @default.
• W3083695748 cites W2155121017 @default.
• W3083695748 cites W2155658630 @default.
• W3083695748 cites W2156760391 @default.
• W3083695748 cites W2159394707 @default.
• W3083695748 cites W2159422401 @default.
• W3083695748 cites W2162176594 @default.
• W3083695748 cites W2163904781 @default.
• W3083695748 cites W2164619984 @default.
• W3083695748 cites W2167579038 @default.
• W3083695748 cites W2168650790 @default.
• W3083695748 cites W2204688218 @default.
• W3083695748 cites W2215535790 @default.
• W3083695748 cites W2262495123 @default.
• W3083695748 cites W2282032965 @default.
• W3083695748 cites W2303094910 @default.
• W3083695748 cites W2399261310 @default.
• W3083695748 cites W2413052899 @default.
• W3083695748 cites W2461793432 @default.
• W3083695748 cites W2470709274 @default.
• W3083695748 cites W2472052306 @default.
• W3083695748 cites W2488598394 @default.
• W3083695748 cites W2513699385 @default.
• W3083695748 cites W2546734246 @default.
• W3083695748 cites W2550685331 @default.
• W3083695748 cites W2560686317 @default.
• W3083695748 cites W2579503198 @default.
• W3083695748 cites W2591123944 @default.
• W3083695748 cites W2593775922 @default.
• W3083695748 cites W2594223161 @default.
• W3083695748 cites W2595016203 @default.
• W3083695748 cites W2600893857 @default.
• W3083695748 cites W2602460727 @default.
• W3083695748 cites W2604330283 @default.
• W3083695748 cites W2607779679 @default.
• W3083695748 cites W2610773212 @default.
• W3083695748 cites W2619692554 @default.
• W3083695748 cites W2704483524 @default.
• W3083695748 cites W2724740917 @default.
• W3083695748 cites W2746863374 @default.
• W3083695748 cites W2748918265 @default.
• W3083695748 cites W2753307501 @default.
• W3083695748 cites W2761254197 @default.
• W3083695748 cites W2766483758 @default.
• W3083695748 cites W2767309773 @default.
• W3083695748 cites W2767917689 @default.
• W3083695748 cites W2769586378 @default.
• W3083695748 cites W2773177533 @default.

• next