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- W3083730150 abstract "Abstract Cancer is one of the deadliest diseases with increasing incidence numbers. This makes the understanding of cancer development and therapeutic resistance crucial to overcome these statistics. Metabolic reprogramming is a significant topic in oncobiology research and a promising target for cancer therapy. Energy requirements, to sustain solid tumor development, are high and cancer cells adapt their metabolism in response to different stimuli. This metabolic plasticity complicates the efficacy of anticancer therapies. The development of anticancer therapeutic strategies involves in vitro and in vivo procedures. Commonly, researchers use two-dimensional cell culture systems as the major in vitro model. However, the lack of tumor microenvironment (TME) interactions and other characteristics deviate this model from what happens in an in vivo tumor. On the other hand, three-dimensional cell culture systems allow the researchers to reproduce more accurately the TME and metabolic profile, allowing also a more efficient evaluation of the newly anticancer strategies developed." @default.
- W3083730150 created "2020-09-11" @default.
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- W3083730150 date "2020-01-01" @default.
- W3083730150 modified "2023-09-26" @default.
- W3083730150 title "3D culture systems as models for solid tumors and cancer metabolism" @default.
- W3083730150 doi "https://doi.org/10.1016/b978-0-12-818128-7.00006-x" @default.
- W3083730150 hasPublicationYear "2020" @default.
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