FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083745584> ?p ?o ?g. }

• W3083745584 endingPage "7895" @default.
• W3083745584 startingPage "7888" @default.
• W3083745584 abstract "Abstract Background Anti‐cancer drugs are approved typically on the basis of efficacy and safety as evaluated in phase III randomized trials (RCTs). Health‐related quality of life (HRQoL) is a direct measure of patient benefit, but is under‐reported. Here we explore associations with reporting of HRQoL data in phase III RCTs in common solid tumors. Methods We searched ClinicalTrials.gov to identify phase III RCTs evaluating new drugs in adults with advanced cancers that completed accrual between January 2005 and October 2016. Data on HRQoL, safety, and tolerability comprising treatment‐related death, treatment discontinuation and commonly reported grade 3 or 4 adverse events (AEs) were extracted. Associations between these measures and reporting of HRQoL data were explored using logistic regression. Results Of 377 phase III RCTs identified initially, 143 studies were analysed and comprised 55% positive trials and 90% industry sponsored trials. HRQoL was listed as an endpoint in 59% trials; and of these, only 65% reported HRQoL data. There were higher odds of reporting HRQoL data for positive trials (OR 2.05, P = .04) and trials published in journals with higher impact factor (OR 1.35, P = .01). Reporting of HRQoL was not associated with treatment‐related death (OR 1.25, P = .40) or treatment discontinuation (OR 1.12, P = .61), but was positively associated with dyspnea and dermatological adverse events. Conclusions HRQoL is reported in only two‐thirds of RCTs that describe collecting such data. Reporting of HRQoL is associated with positive trial outcome and higher journal impact factor, but not associated with overall safety and tolerability of anti‐cancer drugs." @default.
• W3083745584 created "2020-09-11" @default.
• W3083745584 creator A5016909544 @default.
• W3083745584 creator A5029892704 @default.
• W3083745584 creator A5048283327 @default.
• W3083745584 creator A5054881858 @default.
• W3083745584 creator A5059574419 @default.
• W3083745584 creator A5074500372 @default.
• W3083745584 creator A5074810713 @default.
• W3083745584 creator A5081823264 @default.
• W3083745584 date "2020-09-04" @default.
• W3083745584 modified "2023-10-17" @default.
• W3083745584 title "Associations between safety, tolerability, and toxicity and the reporting of health‐related quality of life in phase III randomized trials in common solid tumors" @default.
• W3083745584 cites W1595184853 @default.
• W3083745584 cites W2002973809 @default.
• W3083745584 cites W2021158896 @default.
• W3083745584 cites W2028235117 @default.
• W3083745584 cites W2055753418 @default.
• W3083745584 cites W2070309415 @default.
• W3083745584 cites W2072805665 @default.
• W3083745584 cites W2087202287 @default.
• W3083745584 cites W2097939049 @default.
• W3083745584 cites W2107328434 @default.
• W3083745584 cites W2120100340 @default.
• W3083745584 cites W2134119471 @default.
• W3083745584 cites W2136919572 @default.
• W3083745584 cites W2139436147 @default.
• W3083745584 cites W2139562398 @default.
• W3083745584 cites W2148666312 @default.
• W3083745584 cites W2170952317 @default.
• W3083745584 cites W2171154436 @default.
• W3083745584 cites W2178360273 @default.
• W3083745584 cites W2344407614 @default.
• W3083745584 cites W2344792835 @default.
• W3083745584 cites W2413636075 @default.
• W3083745584 cites W2467898110 @default.
• W3083745584 cites W2496650461 @default.
• W3083745584 cites W2541722967 @default.
• W3083745584 cites W2558674288 @default.
• W3083745584 cites W2625774589 @default.
• W3083745584 cites W2636746695 @default.
• W3083745584 cites W2767785601 @default.
• W3083745584 cites W2782908833 @default.
• W3083745584 cites W2799371667 @default.
• W3083745584 cites W2893152123 @default.
• W3083745584 cites W2897807341 @default.
• W3083745584 cites W2899320385 @default.
• W3083745584 cites W2899353411 @default.
• W3083745584 cites W2914877541 @default.
• W3083745584 cites W2920947255 @default.
• W3083745584 cites W2945139022 @default.
• W3083745584 cites W2984767473 @default.
• W3083745584 cites W2998951754 @default.
• W3083745584 cites W4376849475 @default.
• W3083745584 doi "https://doi.org/10.1002/cam4.3390" @default.
• W3083745584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7643655" @default.
• W3083745584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32886422" @default.
• W3083745584 hasPublicationYear "2020" @default.
• W3083745584 type Work @default.
• W3083745584 sameAs 3083745584 @default.
• W3083745584 citedByCount "3" @default.
• W3083745584 countsByYear W30837455842021 @default.
• W3083745584 countsByYear W30837455842022 @default.
• W3083745584 crossrefType "journal-article" @default.
• W3083745584 hasAuthorship W3083745584A5016909544 @default.
• W3083745584 hasAuthorship W3083745584A5029892704 @default.
• W3083745584 hasAuthorship W3083745584A5048283327 @default.
• W3083745584 hasAuthorship W3083745584A5054881858 @default.
• W3083745584 hasAuthorship W3083745584A5059574419 @default.
• W3083745584 hasAuthorship W3083745584A5074500372 @default.
• W3083745584 hasAuthorship W3083745584A5074810713 @default.
• W3083745584 hasAuthorship W3083745584A5081823264 @default.
• W3083745584 hasBestOaLocation W30837455841 @default.
• W3083745584 hasConcept C126322002 @default.
• W3083745584 hasConcept C156957248 @default.
• W3083745584 hasConcept C159110408 @default.
• W3083745584 hasConcept C168563851 @default.
• W3083745584 hasConcept C197934379 @default.
• W3083745584 hasConcept C2778375690 @default.
• W3083745584 hasConcept C2778715236 @default.
• W3083745584 hasConcept C2779951463 @default.
• W3083745584 hasConcept C535046627 @default.
• W3083745584 hasConcept C71924100 @default.
• W3083745584 hasConceptScore W3083745584C126322002 @default.
• W3083745584 hasConceptScore W3083745584C156957248 @default.
• W3083745584 hasConceptScore W3083745584C159110408 @default.
• W3083745584 hasConceptScore W3083745584C168563851 @default.
• W3083745584 hasConceptScore W3083745584C197934379 @default.
• W3083745584 hasConceptScore W3083745584C2778375690 @default.
• W3083745584 hasConceptScore W3083745584C2778715236 @default.
• W3083745584 hasConceptScore W3083745584C2779951463 @default.
• W3083745584 hasConceptScore W3083745584C535046627 @default.
• W3083745584 hasConceptScore W3083745584C71924100 @default.
• W3083745584 hasIssue "21" @default.
• W3083745584 hasLocation W30837455841 @default.
• W3083745584 hasLocation W30837455842 @default.
• W3083745584 hasOpenAccess W3083745584 @default.
• W3083745584 hasPrimaryLocation W30837455841 @default.

• next