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- W3083753990 abstract "Setting Mannose binding protein gene polymorphism in pulmonary tuberculosis in India.Objective: To find out whether non-HLA genes such as mannose binding protein (MBP) genes are associated in thesusceptibility to pulmonary tuberculosis.Design: Genotyping of MBP 52, 54 and 57 wild and mutant alleles was carried out in HLA-DR typed pulmonarytuberculosis patients (n=202) and control subjects (n=109). Since HLA-DR2 is associated with pulmonary-TB, theinteraction of MBP genes on -DR2 and non-DR2 genes on the susceptibility was also studied.Results: A significantly increased genotype frequency of MBP functional mutant homozygotes (including 52, 54 and57) was seen in pulmonary tuberculosis (PTB) patients (10.9%) than in control subjects (1.8%; P=0.008; odds ratio:6.5). Analysis of interaction of MBP genes and HLA-DR2 on the susceptibility to PTB revealed that these genes areassociated with PTB independent of each other.Conclusion: The present study shows that functional mutants of MBP are associated with PTB. Apart from HLA-DR2association, association of non-HLA genes in the susceptibility to PTB is evident. This suggests that multigeneticfactors (candidate genes) may be involved in the susceptibility/resistance to PTB." @default.
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- W3083753990 date "1999-01-01" @default.
- W3083753990 modified "2023-09-22" @default.
- W3083753990 title "Association of functional mutanthomozygotes of the mannose bindingprotein gene with susceptibility topulmonary tuberculosis in India" @default.
- W3083753990 hasPublicationYear "1999" @default.
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