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- W3083769997 endingPage "109773" @default.
- W3083769997 startingPage "109773" @default.
- W3083769997 abstract "The IL-1 family of cytokines and receptors are critical regulators of inflammation. Within the IL-1 family and in contrast to its IL-1 and IL-18 subfamilies, the IL-36 subfamily is still poorly characterized. Three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, one IL-36 receptor (IL-1R6) antagonist, IL-36RA, and one putative IL-1R6 antagonist, IL-38, have been grouped into the IL-36 cytokine subfamily. IL-36 agonists signal through a common receptor complex to serve as early triggers of inflammatory responses by activating and cross-regulating a number of inflammatory pathways including NF-κB, MAPK and IFN signaling. IL-36RA binds to IL-1R6 to limit inflammatory signaling, while IL-38 may be an antagonist of more than one IL-1 family receptor. Expression patterns of IL-36 family cytokines, being most prominently expressed in epithelial barrier tissues such as the skin and intestines as well as in immune cells, suggest a role in protecting these barriers from infection. Dysregulation of IL-36 family cytokine signaling at physiological barriers, most prominently the skin, induces autoimmune inflammation. However, transferring the potential of IL-36 to induce tissue damage to tumors might benefit cancer patients. Here we summarize signaling pathways regulated by IL-36 family cytokines, including IL-38, and the consequences for physiological protective and pathophysiological destructive inflammation. Moreover, we discuss the limits of current knowledge on IL-36 family function to open potential avenues for research in the future." @default.
- W3083769997 created "2020-09-14" @default.
- W3083769997 creator A5032227105 @default.
- W3083769997 creator A5037907291 @default.
- W3083769997 creator A5052181125 @default.
- W3083769997 creator A5052861559 @default.
- W3083769997 creator A5056936426 @default.
- W3083769997 creator A5082324344 @default.
- W3083769997 date "2020-11-01" @default.
- W3083769997 modified "2023-10-14" @default.
- W3083769997 title "IL-36 family cytokines in protective versus destructive inflammation" @default.
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