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• W3083801735 endingPage "201" @default.
• W3083801735 startingPage "177" @default.
• W3083801735 abstract "Cannabis and cannabinoid-based extracts have long been utilized for their perceived therapeutic value, and support for the legalization of cannabis for medicinal purposes continues to increase worldwide. Since the discovery of Δ9-tetrahydrocannabinol (THC) as the primary psychoactive component of cannabis over 50 years ago, substantial effort has been directed toward detection of endogenous mediators of cannabinoid activity. The discovery of anandamide and 2-arachidonoylglycerol as two endogenous lipid mediators of cannabinoid-like effects (endocannabinoids) has inspired exponential growth in our understanding of this essential pathway, as well as the pathological conditions that result from dysregulated endocannabinoid signaling. This review examines current knowledge of the endocannabinoid system including metabolic enzymes involved in biosynthesis and degradation and their receptors, and evaluates potential druggable targets for therapeutic intervention." @default.
• W3083801735 created "2020-09-14" @default.
• W3083801735 creator A5058164865 @default.
• W3083801735 creator A5064878479 @default.
• W3083801735 date "2020-01-01" @default.
• W3083801735 modified "2023-09-30" @default.
• W3083801735 title "Druggable Targets in Endocannabinoid Signaling" @default.
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