FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083854732> ?p ?o ?g. }

• W3083854732 abstract "Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that has no effective therapies. Prickle planar cell polarity protein 2 (Prickle2), is an important cytoplasmic regulator of Wnt/PCP signalling. It has been reported that Prickle2 deficiency reduced neurite outgrowth levels in mouse N2a cells and led to autism-like behaviours and hippocampal synaptic dysfunction in mice. However, much less is known about the relationship of Prickle2 to AD pathogenesis. RT-qPCR, Western blot and IHC results showed that the mRNA and protein levels of Prickle2 were reduced in amyloid precursor protein (APP)/PS1 mice. Intracerebral injection of Prickle2-overexpressing AAV9 vectors improved the cognitive deficits in APP/PS1 mice. We also demonstrated that Prickle2 could repress oxidative stress and neuroinflammation, ameliorate the amyloid β (Aβ) plaque pathology and reduce Tau hyperphosphorylation in APP/PS1 mice. Further investigation of the mechanism of Prickle2 in AD revealed that Prickle2 inhibited Wnt/PCP/JNK pathway in vivo and in vitro. The downregulation of GATA2 induced the silencing of Prickle2 by binding its promoter region. Our results suggest that Prickle2 might be a potential candidate for the diagnosis and treatment of AD." @default.
• W3083854732 created "2020-09-14" @default.
• W3083854732 creator A5009045546 @default.
• W3083854732 creator A5017521861 @default.
• W3083854732 creator A5042467158 @default.
• W3083854732 creator A5046734565 @default.
• W3083854732 creator A5050776813 @default.
• W3083854732 creator A5062176670 @default.
• W3083854732 date "2020-09-08" @default.
• W3083854732 modified "2023-09-27" @default.
• W3083854732 title "Upregulation of Prickle2 Ameliorates Alzheimer’s Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer’s Disease" @default.
• W3083854732 cites W1963481639 @default.
• W3083854732 cites W1966030396 @default.
• W3083854732 cites W1983728938 @default.
• W3083854732 cites W1988987349 @default.
• W3083854732 cites W1993795814 @default.
• W3083854732 cites W1996847587 @default.
• W3083854732 cites W1999000375 @default.
• W3083854732 cites W2015974087 @default.
• W3083854732 cites W2017668082 @default.
• W3083854732 cites W2026787985 @default.
• W3083854732 cites W2026982076 @default.
• W3083854732 cites W2034021063 @default.
• W3083854732 cites W2036912839 @default.
• W3083854732 cites W2046422248 @default.
• W3083854732 cites W2048102969 @default.
• W3083854732 cites W2048790780 @default.
• W3083854732 cites W2077146311 @default.
• W3083854732 cites W2096407545 @default.
• W3083854732 cites W2124040795 @default.
• W3083854732 cites W2130393399 @default.
• W3083854732 cites W2138722168 @default.
• W3083854732 cites W2156398762 @default.
• W3083854732 cites W2158204493 @default.
• W3083854732 cites W2256579886 @default.
• W3083854732 cites W2257129080 @default.
• W3083854732 cites W2416788485 @default.
• W3083854732 cites W2566196214 @default.
• W3083854732 cites W2568450381 @default.
• W3083854732 cites W2574984686 @default.
• W3083854732 cites W2587513564 @default.
• W3083854732 cites W2617943552 @default.
• W3083854732 cites W2735472081 @default.
• W3083854732 cites W2754986420 @default.
• W3083854732 cites W2766446922 @default.
• W3083854732 cites W2773748959 @default.
• W3083854732 cites W2779861385 @default.
• W3083854732 cites W2782525747 @default.
• W3083854732 cites W2793605891 @default.
• W3083854732 cites W2798084979 @default.
• W3083854732 cites W2803116439 @default.
• W3083854732 cites W2887669345 @default.
• W3083854732 cites W2889813982 @default.
• W3083854732 cites W2905504149 @default.
• W3083854732 cites W2909242954 @default.
• W3083854732 cites W2930419027 @default.
• W3083854732 cites W2945124452 @default.
• W3083854732 cites W2963537182 @default.
• W3083854732 cites W4234718611 @default.
• W3083854732 doi "https://doi.org/10.3389/fcell.2020.565020" @default.
• W3083854732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7509431" @default.
• W3083854732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33015060" @default.
• W3083854732 hasPublicationYear "2020" @default.
• W3083854732 type Work @default.
• W3083854732 sameAs 3083854732 @default.
• W3083854732 citedByCount "5" @default.
• W3083854732 countsByYear W30838547322022 @default.
• W3083854732 countsByYear W30838547322023 @default.
• W3083854732 crossrefType "journal-article" @default.
• W3083854732 hasAuthorship W3083854732A5009045546 @default.
• W3083854732 hasAuthorship W3083854732A5017521861 @default.
• W3083854732 hasAuthorship W3083854732A5042467158 @default.
• W3083854732 hasAuthorship W3083854732A5046734565 @default.
• W3083854732 hasAuthorship W3083854732A5050776813 @default.
• W3083854732 hasAuthorship W3083854732A5062176670 @default.
• W3083854732 hasBestOaLocation W30838547321 @default.
• W3083854732 hasConcept C102230213 @default.
• W3083854732 hasConcept C104317684 @default.
• W3083854732 hasConcept C113246987 @default.
• W3083854732 hasConcept C119056186 @default.
• W3083854732 hasConcept C127561419 @default.
• W3083854732 hasConcept C137620995 @default.
• W3083854732 hasConcept C141035611 @default.
• W3083854732 hasConcept C142724271 @default.
• W3083854732 hasConcept C148762608 @default.
• W3083854732 hasConcept C169760540 @default.
• W3083854732 hasConcept C175344181 @default.
• W3083854732 hasConcept C184235292 @default.
• W3083854732 hasConcept C202751555 @default.
• W3083854732 hasConcept C203014093 @default.
• W3083854732 hasConcept C2776415932 @default.
• W3083854732 hasConcept C2776914184 @default.
• W3083854732 hasConcept C2776925932 @default.
• W3083854732 hasConcept C2778198054 @default.
• W3083854732 hasConcept C2779134260 @default.
• W3083854732 hasConcept C2779830541 @default.
• W3083854732 hasConcept C31705614 @default.
• W3083854732 hasConcept C502032728 @default.
• W3083854732 hasConcept C55493867 @default.
• W3083854732 hasConcept C62478195 @default.

• next