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- W3083854782 abstract "Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature during development, after which Tregs persist as a self-renewing population that regulates immune system activation. Whether maintenance DNA methylation is required for Treg lineage development and stability and how methylation patterns are maintained during lineage self-renewal remain unclear. Here, we demonstrate that the epigenetic regulator ubiquitin-like with plant homeodomain and RING finger domains 1 (Uhrf1) is essential for maintenance of methyl-DNA marks that stabilize Treg cellular identity by repressing effector T cell transcriptional programs. Constitutive and induced deficiency of Uhrf1 within Foxp3+ cells resulted in global yet nonuniform loss of DNA methylation, derepression of inflammatory transcriptional programs, destabilization of the Treg lineage, and spontaneous inflammation. These findings support a paradigm in which maintenance DNA methylation is required in distinct regions of the Treg genome for both lineage establishment and stability of identity and suppressive function." @default.
- W3083854782 created "2020-09-14" @default.
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- W3083854782 date "2020-11-09" @default.
- W3083854782 modified "2023-10-14" @default.
- W3083854782 title "Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function" @default.
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- W3083854782 doi "https://doi.org/10.1172/jci137712" @default.
- W3083854782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7710299" @default.
- W3083854782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32897881" @default.
- W3083854782 hasPublicationYear "2020" @default.
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