Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083856063> ?p ?o ?g. }
- W3083856063 endingPage "735926" @default.
- W3083856063 startingPage "735926" @default.
- W3083856063 abstract "Peptides with antimicrobial potential can now be easily and efficiently predicted, designed and validated using in silico tools. Here, twelve peptides with molecular weights between 1.6 and 1.8 kDa were predicted from the sequence of the small subunit of Penaeus vannamei hemocyanin (PvHS) using three online software (AntiBP2, CAMP and APD3). Among the twelve predicted peptides, two peptides, PvHS8 and PvHS9, with the highest prediction score, were selected and their antimicrobial activities ascertained. Both peptide PvHS8 and PvHS9 had strong antimicrobial activity on Gram-negative (i.e., Vibrio parahaemolyticus, Vibrio fluvialis, Vibrio alginolyticus, Escherichia coli, and Aeromonas hydrophila) and Gram-positive (i.e., Staphylococcus aureus, Streptococcus iniae) bacteria, with PvHS9 having the strongest activity. Structural analysis using circular dichroism (CD) and nuclear magnetic resonance (NMR) revealed that peptide PvHS9 (FWVSLKGGKTSIERK) has a β-sheet structure. Mutation of PvHS9 to distort its β-sheet structure and net positive charge attenuated its antimicrobial activity. In addition, scanning electron microscopy (SEM) analysis revealed that peptide PvHS9 destroys bacteria cells by causing membrane rupture and cell death." @default.
- W3083856063 created "2020-09-14" @default.
- W3083856063 creator A5000326646 @default.
- W3083856063 creator A5030005775 @default.
- W3083856063 creator A5042466812 @default.
- W3083856063 creator A5042945455 @default.
- W3083856063 creator A5057855424 @default.
- W3083856063 creator A5086946220 @default.
- W3083856063 date "2021-01-01" @default.
- W3083856063 modified "2023-10-13" @default.
- W3083856063 title "PvHS9 is a novel in silico predicted antimicrobial peptide derived from hemocyanin of Penaeus vannamei" @default.
- W3083856063 cites W1486212524 @default.
- W3083856063 cites W1831312869 @default.
- W3083856063 cites W1970707083 @default.
- W3083856063 cites W1976434141 @default.
- W3083856063 cites W1992603413 @default.
- W3083856063 cites W1997152791 @default.
- W3083856063 cites W2011879749 @default.
- W3083856063 cites W2012276417 @default.
- W3083856063 cites W2015786049 @default.
- W3083856063 cites W2019783520 @default.
- W3083856063 cites W2027376389 @default.
- W3083856063 cites W2045897279 @default.
- W3083856063 cites W2052590400 @default.
- W3083856063 cites W2055683362 @default.
- W3083856063 cites W2057339191 @default.
- W3083856063 cites W2067251729 @default.
- W3083856063 cites W2072498561 @default.
- W3083856063 cites W2072842607 @default.
- W3083856063 cites W2074922563 @default.
- W3083856063 cites W2084283000 @default.
- W3083856063 cites W2086851276 @default.
- W3083856063 cites W2103461051 @default.
- W3083856063 cites W2112862199 @default.
- W3083856063 cites W2122428319 @default.
- W3083856063 cites W2124700733 @default.
- W3083856063 cites W2140839919 @default.
- W3083856063 cites W2149854734 @default.
- W3083856063 cites W2166095803 @default.
- W3083856063 cites W2191271444 @default.
- W3083856063 cites W2403690088 @default.
- W3083856063 cites W2415586769 @default.
- W3083856063 cites W2513553669 @default.
- W3083856063 cites W2614793868 @default.
- W3083856063 cites W2625108725 @default.
- W3083856063 cites W2766758765 @default.
- W3083856063 cites W2766941699 @default.
- W3083856063 cites W2781833354 @default.
- W3083856063 cites W2792764216 @default.
- W3083856063 cites W2800263663 @default.
- W3083856063 cites W2802706449 @default.
- W3083856063 cites W2896974443 @default.
- W3083856063 cites W2897058203 @default.
- W3083856063 cites W2899121039 @default.
- W3083856063 cites W2902591970 @default.
- W3083856063 cites W2906960763 @default.
- W3083856063 cites W2950991123 @default.
- W3083856063 cites W2976004469 @default.
- W3083856063 cites W2981661656 @default.
- W3083856063 cites W2995510585 @default.
- W3083856063 cites W3007224086 @default.
- W3083856063 cites W3022458695 @default.
- W3083856063 cites W3034936296 @default.
- W3083856063 doi "https://doi.org/10.1016/j.aquaculture.2020.735926" @default.
- W3083856063 hasPublicationYear "2021" @default.
- W3083856063 type Work @default.
- W3083856063 sameAs 3083856063 @default.
- W3083856063 citedByCount "9" @default.
- W3083856063 countsByYear W30838560632021 @default.
- W3083856063 countsByYear W30838560632022 @default.
- W3083856063 countsByYear W30838560632023 @default.
- W3083856063 crossrefType "journal-article" @default.
- W3083856063 hasAuthorship W3083856063A5000326646 @default.
- W3083856063 hasAuthorship W3083856063A5030005775 @default.
- W3083856063 hasAuthorship W3083856063A5042466812 @default.
- W3083856063 hasAuthorship W3083856063A5042945455 @default.
- W3083856063 hasAuthorship W3083856063A5057855424 @default.
- W3083856063 hasAuthorship W3083856063A5086946220 @default.
- W3083856063 hasConcept C104317684 @default.
- W3083856063 hasConcept C147483822 @default.
- W3083856063 hasConcept C203014093 @default.
- W3083856063 hasConcept C2775905019 @default.
- W3083856063 hasConcept C2776154503 @default.
- W3083856063 hasConcept C2776575720 @default.
- W3083856063 hasConcept C2778968793 @default.
- W3083856063 hasConcept C2779281246 @default.
- W3083856063 hasConcept C2779441561 @default.
- W3083856063 hasConcept C2779915011 @default.
- W3083856063 hasConcept C4937899 @default.
- W3083856063 hasConcept C523546767 @default.
- W3083856063 hasConcept C540938839 @default.
- W3083856063 hasConcept C54355233 @default.
- W3083856063 hasConcept C547475151 @default.
- W3083856063 hasConcept C55493867 @default.
- W3083856063 hasConcept C86803240 @default.
- W3083856063 hasConcept C89423630 @default.
- W3083856063 hasConceptScore W3083856063C104317684 @default.
- W3083856063 hasConceptScore W3083856063C147483822 @default.