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• W3083862941 endingPage "99" @default.
• W3083862941 startingPage "71" @default.
• W3083862941 abstract "Bioactive lipid mediators resulting from the metabolism of polyunsaturated fatty acids (PUFA) are controlled by many pathways that regulate the levels of these mediators and maintain homeostasis to prevent disease. PUFA metabolism is driven primarily through three pathways. Two pathways, the cyclooxygenase (COX) and lipoxygenase (LO) enzymatic pathways, form metabolites that are mostly inflammatory, while the third route of metabolism results from the oxidation by the cytochrome P450 enzymes to form hydroxylated PUFA and epoxide metabolites. These epoxygenated fatty acids (EpFA) demonstrate largely anti-inflammatory and beneficial properties, in contrast to the other metabolites formed from the degradation of PUFA. Dysregulation of these systems often leads to chronic disease. Pharmaceutical targets of disease focus on preventing the formation of inflammatory metabolites from the COX and LO pathways, while maintaining the EpFA and increasing their concentration in the body is seen as beneficial to treating and preventing disease. The soluble epoxide hydrolase (sEH) is the major route of metabolism of EpFA. Inhibiting its activity increases concentrations of beneficial EpFA, and often disease states correlate to mutations in the sEH enzyme that increase its activity and decrease the concentrations of EpFA in the body. Recent approaches to increasing EpFA include synthetic mimics that replicate biological activity of EpFA while preventing their metabolism, while other approaches focus on developing small molecule inhibitors to the sEH. Increasing EpFA concentrations in the body has demonstrated multiple beneficial effects in treating many diseases, including inflammatory and painful conditions, cardiovascular disease, neurological and disease of the central nervous system. Demonstration of efficacy in so many disease states can be explained by the fundamental mechanism that EpFA have of maintaining healthy microvasculature and preventing mitochondrial and endoplasmic reticulum stress. While there are no FDA approved methods that target the sEH or other enzymes responsible for metabolizing EpFA, current clinical efforts to test for efficacy by increasing EpFA that include inhibiting the sEH or administration of EpFA mimics that block metabolism are in progress." @default.
• W3083862941 created "2020-09-14" @default.
• W3083862941 creator A5013909385 @default.
• W3083862941 creator A5026538320 @default.
• W3083862941 creator A5031532167 @default.
• W3083862941 creator A5054061818 @default.
• W3083862941 date "2020-01-01" @default.
• W3083862941 modified "2023-10-13" @default.
• W3083862941 title "Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation" @default.
• W3083862941 cites W1235737020 @default.
• W3083862941 cites W1485218631 @default.
• W3083862941 cites W1513508185 @default.
• W3083862941 cites W1895242283 @default.
• W3083862941 cites W1913730804 @default.
• W3083862941 cites W1940688833 @default.
• W3083862941 cites W1966480836 @default.
• W3083862941 cites W1967703805 @default.
• W3083862941 cites W1969307895 @default.
• W3083862941 cites W1972281497 @default.
• W3083862941 cites W1973847365 @default.
• W3083862941 cites W1975272363 @default.
• W3083862941 cites W1980978175 @default.
• W3083862941 cites W1987124995 @default.
• W3083862941 cites W1987400532 @default.
• W3083862941 cites W1992303064 @default.
• W3083862941 cites W1995454938 @default.
• W3083862941 cites W2000100678 @default.
• W3083862941 cites W2001592532 @default.
• W3083862941 cites W2003582333 @default.
• W3083862941 cites W2004193154 @default.
• W3083862941 cites W2006570043 @default.
• W3083862941 cites W2006634108 @default.
• W3083862941 cites W2008574207 @default.
• W3083862941 cites W2013555445 @default.
• W3083862941 cites W2014555233 @default.
• W3083862941 cites W2016529877 @default.
• W3083862941 cites W2016860607 @default.
• W3083862941 cites W2017586743 @default.
• W3083862941 cites W2018319340 @default.
• W3083862941 cites W2021065154 @default.
• W3083862941 cites W2024381797 @default.
• W3083862941 cites W2027504703 @default.
• W3083862941 cites W2029862970 @default.
• W3083862941 cites W2030824198 @default.
• W3083862941 cites W2038222125 @default.
• W3083862941 cites W2043769668 @default.
• W3083862941 cites W2047786869 @default.
• W3083862941 cites W2052091534 @default.
• W3083862941 cites W2055091617 @default.
• W3083862941 cites W2056058231 @default.
• W3083862941 cites W2057910997 @default.
• W3083862941 cites W2061755061 @default.
• W3083862941 cites W2061869396 @default.
• W3083862941 cites W2061956345 @default.
• W3083862941 cites W2063268769 @default.
• W3083862941 cites W2065329019 @default.
• W3083862941 cites W2065971285 @default.
• W3083862941 cites W2067983286 @default.
• W3083862941 cites W2070696860 @default.
• W3083862941 cites W2084260196 @default.
• W3083862941 cites W2086889046 @default.
• W3083862941 cites W2088233980 @default.
• W3083862941 cites W2088848230 @default.
• W3083862941 cites W2089031969 @default.
• W3083862941 cites W2090609282 @default.
• W3083862941 cites W2090654564 @default.
• W3083862941 cites W2093250429 @default.
• W3083862941 cites W2093914979 @default.
• W3083862941 cites W2100717822 @default.
• W3083862941 cites W2100941332 @default.
• W3083862941 cites W2102540068 @default.
• W3083862941 cites W2107738379 @default.
• W3083862941 cites W2108772785 @default.
• W3083862941 cites W2109939117 @default.
• W3083862941 cites W2111656201 @default.
• W3083862941 cites W2116704287 @default.
• W3083862941 cites W2120014586 @default.
• W3083862941 cites W2121612196 @default.
• W3083862941 cites W212643890 @default.
• W3083862941 cites W2127587566 @default.
• W3083862941 cites W2127722031 @default.
• W3083862941 cites W2129077714 @default.
• W3083862941 cites W2129307177 @default.
• W3083862941 cites W2130923919 @default.
• W3083862941 cites W2133252415 @default.
• W3083862941 cites W2140226240 @default.
• W3083862941 cites W2142219464 @default.
• W3083862941 cites W2145630011 @default.
• W3083862941 cites W2149675148 @default.
• W3083862941 cites W2151831055 @default.
• W3083862941 cites W2152309980 @default.
• W3083862941 cites W2152584784 @default.
• W3083862941 cites W2154473687 @default.
• W3083862941 cites W2154881563 @default.
• W3083862941 cites W2160308798 @default.
• W3083862941 cites W2160712561 @default.
• W3083862941 cites W2162233719 @default.
• W3083862941 cites W2162679859 @default.

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