FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3083874241> ?p ?o ?g. }

• W3083874241 abstract "Abstract The genetic code is degenerate, and most amino acids are encoded by two to six synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a universal feature of all genomes examined. Synonymous codon mutations were previously thought to be silent; however, a growing body evidence now shows that codon usage regulates protein structure and gene expression through effects on co-translational protein folding, translation efficiency and accuracy, mRNA stability, and transcription. Codon usage regulates the speed of translation elongation, resulting in non-uniform ribosome decoding rates on mRNAs during translation that is adapted to co-translational protein folding process. Biochemical and genetic evidence demonstrate that codon usage plays an important role in regulating protein folding and function in both prokaryotic and eukaryotic organisms. Certain protein structural types are more sensitive than others to the effects of codon usage on protein folding, and predicted intrinsically disordered domains are more prone to misfolding caused by codon usage changes than other domain types. Bioinformatic analyses revealed that gene codon usage correlates with different protein structures in diverse organisms, indicating the existence of a codon usage code for co-translational protein folding. This review focuses on recent literature on the role and mechanism of codon usage in regulating translation kinetics and co-translational protein folding." @default.
• W3083874241 created "2020-09-14" @default.
• W3083874241 creator A5083956868 @default.
• W3083874241 date "2020-09-09" @default.
• W3083874241 modified "2023-10-16" @default.
• W3083874241 title "A code within the genetic code: codon usage regulates co-translational protein folding" @default.
• W3083874241 cites W1524157974 @default.
• W3083874241 cites W1539868719 @default.
• W3083874241 cites W1589192533 @default.
• W3083874241 cites W1593377767 @default.
• W3083874241 cites W1794015648 @default.
• W3083874241 cites W1956613997 @default.
• W3083874241 cites W1966778471 @default.
• W3083874241 cites W1968654669 @default.
• W3083874241 cites W1974358663 @default.
• W3083874241 cites W1974394989 @default.
• W3083874241 cites W1980274160 @default.
• W3083874241 cites W1984512854 @default.
• W3083874241 cites W1986720579 @default.
• W3083874241 cites W1993358499 @default.
• W3083874241 cites W2000269014 @default.
• W3083874241 cites W2006192061 @default.
• W3083874241 cites W2008589209 @default.
• W3083874241 cites W2013321787 @default.
• W3083874241 cites W2013354180 @default.
• W3083874241 cites W2024254552 @default.
• W3083874241 cites W2029132648 @default.
• W3083874241 cites W2031141147 @default.
• W3083874241 cites W2035557248 @default.
• W3083874241 cites W2035926239 @default.
• W3083874241 cites W2036690617 @default.
• W3083874241 cites W2037145016 @default.
• W3083874241 cites W2038941962 @default.
• W3083874241 cites W2039790548 @default.
• W3083874241 cites W2042548693 @default.
• W3083874241 cites W2042700625 @default.
• W3083874241 cites W2051043527 @default.
• W3083874241 cites W2055536178 @default.
• W3083874241 cites W2056029668 @default.
• W3083874241 cites W2058864686 @default.
• W3083874241 cites W2060421156 @default.
• W3083874241 cites W2065049493 @default.
• W3083874241 cites W2066829062 @default.
• W3083874241 cites W2068628419 @default.
• W3083874241 cites W2069320301 @default.
• W3083874241 cites W2071849521 @default.
• W3083874241 cites W2072499238 @default.
• W3083874241 cites W2075158468 @default.
• W3083874241 cites W2078010704 @default.
• W3083874241 cites W2078146553 @default.
• W3083874241 cites W2078461833 @default.
• W3083874241 cites W2079517684 @default.
• W3083874241 cites W2085522899 @default.
• W3083874241 cites W2087439897 @default.
• W3083874241 cites W2092035637 @default.
• W3083874241 cites W2094148055 @default.
• W3083874241 cites W2094338137 @default.
• W3083874241 cites W2097891553 @default.
• W3083874241 cites W2106253512 @default.
• W3083874241 cites W2109207481 @default.
• W3083874241 cites W2122611378 @default.
• W3083874241 cites W2126096918 @default.
• W3083874241 cites W2127161280 @default.
• W3083874241 cites W2139839186 @default.
• W3083874241 cites W2141997506 @default.
• W3083874241 cites W2145203699 @default.
• W3083874241 cites W2149424410 @default.
• W3083874241 cites W2154232977 @default.
• W3083874241 cites W2158850411 @default.
• W3083874241 cites W2160215304 @default.
• W3083874241 cites W2166752189 @default.
• W3083874241 cites W2171166041 @default.
• W3083874241 cites W2184623063 @default.
• W3083874241 cites W2257602426 @default.
• W3083874241 cites W2259283565 @default.
• W3083874241 cites W2278619766 @default.
• W3083874241 cites W2298977477 @default.
• W3083874241 cites W2346811503 @default.
• W3083874241 cites W2466333954 @default.
• W3083874241 cites W2495238549 @default.
• W3083874241 cites W2516990920 @default.
• W3083874241 cites W2524169008 @default.
• W3083874241 cites W2560234147 @default.
• W3083874241 cites W2608970480 @default.
• W3083874241 cites W2611528178 @default.
• W3083874241 cites W2614053601 @default.
• W3083874241 cites W2616018166 @default.
• W3083874241 cites W2620912806 @default.
• W3083874241 cites W2762868004 @default.
• W3083874241 cites W2771199102 @default.
• W3083874241 cites W2790467596 @default.
• W3083874241 cites W2793056129 @default.
• W3083874241 cites W2793389063 @default.
• W3083874241 cites W2888885392 @default.
• W3083874241 cites W2895235691 @default.
• W3083874241 cites W2940525406 @default.
• W3083874241 cites W2950711038 @default.
• W3083874241 cites W2962967898 @default.
• W3083874241 cites W2967708187 @default.
• W3083874241 cites W2982639824 @default.

• next