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• W3083890889 abstract "Biological timekeeping enables the coordination and execution of complex cellular processes such as developmental programs, day/night organismal changes, intercellular signaling, and proliferative safeguards. While these systems are often considered separately owing to a wide variety of mechanisms, time frames, and outputs, all clocks are built by calibrating or delaying the rate of biochemical reactions and processes. In this review, we explore the common themes and core design principles of cellular clocks, giving special consideration to the challenges associated with building timers from biochemical components. We also outline how evolution has coopted time to increase the reliability of a diverse range of biological systems." @default.
• W3083890889 created "2020-09-14" @default.
• W3083890889 creator A5001482747 @default.
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• W3083890889 date "2020-09-09" @default.
• W3083890889 modified "2023-10-17" @default.
• W3083890889 title "Keeping track of time: The fundamentals of cellular clocks" @default.
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• W3083890889 doi "https://doi.org/10.1083/jcb.202005136" @default.
• W3083890889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7594491" @default.
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• W3083890889 hasPublicationYear "2020" @default.
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